Evidence map›Paper›PMID 40186827›Full record

ArticleJournal of molecular histology2025

Synergistic salvation: HIIT and herbal allies reverse NAFLD damage in rats.

Ehsan Arabzadeh, Amir Sarshin, Foad Feizolahi, Majid Mohabbat, Mohammad-Ali Soleiman-Fallah, Alireza Rahimi, Anatoli Petridou, Zahra Emami, Helena Tajik, Reza Bozorg Omid and 4 more

Abstract read
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Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ehsan ArabzadehExercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Amir SarshinClinical Care and Health Promotion Research Center, Karaj Branch, Islamic Azad University, Karaj, Iran.
Foad FeizolahiClinical Care and Health Promotion Research Center, Karaj Branch, Islamic Azad University, Karaj, Iran.
Majid MohabbatDepartment of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.
Mohammad-Ali Soleiman-FallahDepartment of Sport Biomechanics, Karaj Branch, Islamic Azad University, Karaj, Iran.
Alireza RahimiDepartment of Exercise Physiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Anatoli PetridouLaboratory of Evaluation of Human Biological Performance, School of Physical Education and Sport Science at Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Zahra EmamiDepartment of Exercise Physiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Helena TajikDepartment of Exercise Physiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Reza Bozorg OmidDepartment of Exercise Physiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Amir MalekiDepartment of Exercise Physiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Hamid Ekrami OgholbagBasic Medical Science Research Center, Histogenotech Company, Tehran, Iran.
Ali KhademiPhD in Sport Management, Karaj Branch, Islamic Azad University, Karaj, Iran.
Mehdi ZarganiDepartment of Exercise Physiology, Karaj Branch, Islamic Azad University, Karaj, Iran. Zargani1980@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatty liver disease is a build-up of fats in the liver that can damage the organ and lead to serious complications. This study aimed to investigate the effects of exercise training and supplementation (milk thistle, chicory and cumin) on liver metabolites related to its function and health in rats with non-alcoholic fatty liver disease (NAFLD). Forty adult male Wistar rats with an average weight of 215 ± 10 g were divided into a control group fed on the basal diet and four experimental groups fed with high-fat diet (HFD) for 6 weeks to induce non-alcoholic fatty liver disease (NAFLD). The 4 NAFLD groups were subdivided and treated with (a) plain HFD, (b) high-intensity interval training (HIIT), (c) supplement (milk thistle, chicory, and cumin), and (d) combined HIIT and supplementation for 4 weeks. The induction of NAFLD through HFD yielded dyslipidemia, liver tissue damage, increased malondialdehyde, uncoupling protein 2 (UCP2), and phosphatidylinositol-3 kinase (PI3K), as well as decreased superoxide dismutase (SOD) and peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) in liver tissue (p < 0.05). The 4 weeks intervention with either HIIT, supplement or especially the combined application of both, reversed these factors (p < 0.05) through changes in their concentrations in a direction indicative of enhanced liver health and function. HIIT beside supplementation (milk thistle, chicory, and cumin) improved indices related to oxidative stress, lipid profile, and the expression of PI3K, UCP2, PGC-1α genes expression and PGC-1α protein content, making it potentially promising in the treatment of liver damage caused by HFD.

Indexed as

High-Intensity Interval TrainingNon-alcoholic Fatty Liver DiseasePhysical Conditioning, AnimalPlant ExtractsAnimalsCichorium intybusDietary SupplementsDiet, High-FatDisease Models, AnimalLiverMaleOxidative StressRatsRats, WistarUncoupling Protein 2Plant ExtractsUncoupling Protein 2High-intensity interval trainingLipid profileNAFLDOxidative stressSupplement

Identifiers

PMID40186827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.