Evidence map›Paper›PMID 40186822›Full record

ArticleNeuroscience bulletin2025

Histopathological Insights into Demyelination and Remyelination After Spinal Cord Injury in Non-human Primates.

Junhao Liu, Zucheng Huang, Kinon Chen, Rong Li, Zhiping Huang, Junyu Lin, Hui Jiang, Jie Liu, Qingan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junhao Liu *Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zucheng Huang *Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Kinon Chen *Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Rong LiDepartment of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhiping HuangDepartment of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Junyu LinDepartment of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Hui JiangDepartment of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. 33500307@qq.com.
Jie LiuInstitute of Trauma and Orthopedics, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, China. jliu@icord.org.
Qingan ZhuDepartment of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. qinganzhu@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Demyelination and remyelination play key roles in spinal cord injury (SCI), affecting the recovery of motor and sensory functions. Research in rodent models is extensive, but the study of these processes in non-human primates is limited. Therefore, our goal was to thoroughly study the histological features of demyelination and remyelination after contusion injury of the cervical spinal cord in Macaca fascicularis. In a previous study, we created an SCI model in M. fascicularis by controlling the contusion displacement. We used Eriochrome Cyanine staining, immunohistochemical analysis, and toluidine blue staining to evaluate demyelination and remyelination. The results showed demyelination ipsilateral to the injury epicenter both rostrally and caudally, the former mainly impacting sensory pathways, while the latter primarily affected motor pathways. Toluidine blue staining showed myelin loss and axonal distension at the injury site. Schwann cell-derived myelin sheaths were only found at the center, while thinner myelin sheaths from oligodendrocytes were seen at the center and surrounding areas. Our study showed that long-lasting demyelination occurs in the spinal cord of M. fascicularis after SCI, with oligodendrocytes and Schwann cells playing a significant role in myelin sheath formation at the injury site.

Indexed as

Demyelinating DiseasesMyelin SheathRemyelinationSpinal CordSpinal Cord InjuriesAnimalsAxonsDisease Models, AnimalFemaleMacaca fascicularisOligodendrogliaSchwann CellsDemyelinationHistological analysisNon-human primateRemyelinationSpinal cord injury

Identifiers

PMID40186822
PMCPMC12314273

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