Evidence map›Paper›PMID 40186763›Full record

ArticleHepatology international2025

Mindin orchestrates the macrophage-mediated resolution of liver fibrosis in mice.

Yong-Dong Huang, Xian-Ling Zhao, Ying Lin, Xiao-Mei Ouyang, Xiao-Shen Cheng, Lai-Ying Liang, Ya-Ni Huo, Gui-Jing Xie, Jun-Hui Lin, Amarsanaa Jazag and 1 more

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Article in Hepatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yong-Dong Huang *Department of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Xian-Ling Zhao *Department of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Ying Lin *Department of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Xiao-Mei OuyangDepartment of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Xiao-Shen ChengDepartment of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Lai-Ying LiangDepartment of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Ya-Ni HuoDepartment of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Gui-Jing XieDepartment of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Jun-Hui LinDepartment of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China.
Amarsanaa JazagDepartment of Medicine, Otoch Manramba University, Ulaanbaatar, Mongolia.
Bayasi GulengDepartment of Gastroenterology, Zhongshan Hospital of Xiamen University, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361004, China. bayasi@xmu.edu.cn.

Funding

National Natural Science Foundation of China No. 81970460Natural Science Foundation of Fujian Province No. 2023J011598
6 · The paper itself

Abstract

BACKGROUND &

aimsLiver disease that progresses to cirrhosis is an enormous health problem worldwide. The extracellular matrix protein Mindin is known to have immune functions, but its role in liver homeostasis remains largely unexplored. We aimed to characterize the role of Mindin in the regulation of liver fibrosis. APPROACH &

resultsMindin was upregulated in mice with carbon tetrachloride (CCl

conclusionsMindin promotes the resolution of liver fibrosis and the Mindin/CD11b axis might represent a novel target for the macrophage-mediated regression of liver fibrosis.

Indexed as

Extracellular Matrix ProteinsLiver CirrhosisMacrophagesAnimalsCarbon TetrachlorideDisease Models, AnimalHepatic Stellate CellsHepatocytesMaleMiceMice, Inbred C57BLMice, KnockoutPhagocytosisThioacetamideCarbon TetrachlorideExtracellular Matrix ProteinsmindinThioacetamideCD11bDKOExtracellular matrixFlow cytometryHepatic stellate cellLy6CMigrationMMPPhagocytosisPhenotypic switchRestorative macrophages

Identifiers

PMID40186763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.