Evidence map›Paper›PMID 40186757›Full record

ArticleUrolithiasis2025

Analysis of microRNA expression in patients with uric acid calculi.

Sabrina T Reis, William M Simões, Poliana Romão, Patrícia Candido, Lucca J Zampolli, Vanessa R Guimarães, Daniel Ayres, Ruan Pimenta, Katia Ramos Moreira Leite, William C Nahas and 1 more

Abstract read
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In one paragraph

Article in Urolithiasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sabrina T ReisLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil. sabrinareis@usp.br.
William M SimõesLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.
Poliana RomãoLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.
Patrícia CandidoLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.
Lucca J ZampolliLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.
Vanessa R GuimarãesLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.
Daniel AyresLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.
Ruan PimentaLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.
Katia Ramos Moreira LeiteLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.
William C NahasUro-Oncology Group, Urology Department, Institute of Cancer State of São Paulo (ICESP), São Paulo, SP, 01246000, Brazil.
Eduardo MazzucchiLaboratório de Investigação Médica 55 (LIM55), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, 2° floor, room 2145 - Cerqueira Cesar, São Paulo, SP, 01246-903, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uric acid calculi (UAC) account for about 10% of cases worldwide, although this varies among countries. The etiology of nephrolithiasis is multifactorial, involving both genetic and environmental factors. Kidney stones occur three times more frequently in individuals with a family history of the condition compared to those without such a history. Genetic factors also contribute to cases of UAC. Genes such as ZNF365, SLC2A9 and SLC22A12 may be associated with the development of uric acid stones. MicroRNAs (miRNAs) are small RNA molecules, that play a significant role in regulating gene expression. The aim of this study was to characterize the expression profile of miRNAs associated with the SLC2A9, SLC22A12 and ZNF365 genes in patients with uric lithiasis. Twenty-two patients with pure uric stones and 8 controls with no history of lithiasis were included, all of whom consented voluntarily. To analyze the gene expression levels of the microRNAs studied, total RNA was obtained using the miRVana

Indexed as

Kidney CalculiMicroRNAsUric AcidAdultCase-Control StudiesFemaleGlucose Transport Proteins, FacilitativeHumansHyperuricemiaMaleMiddle AgedOrganic Anion TransportersOrganic Cation Transport ProteinsGlucose Transport Proteins, FacilitativeMicroRNAsOrganic Anion TransportersOrganic Cation Transport ProteinsSLC22A12 protein, humanSLC2A9 protein, humanUric AcidGene expressionMicroRNAsRenal calculiUric acid

Identifiers

PMID40186757

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.