Evidence map›Paper›PMID 40186755›Full record

ArticleTechniques in coloproctology2025

Early detection and correction of preoperative anemia in patients undergoing colorectal surgery-a prospective study.

A de Wit, B T Bootsma, D E Huisman, G Kazemier, F Daams, Taskforce Anastomotic Leakage

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Techniques in coloproctology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05250882 (Enhanced Perioperative Care for Improving Outcomes After Colorectal Resection by Implementation of Best Practice for the Prevention of Anastomotic Leakage - Double Check Study), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05250882 naunknown statusnot on this map

Enhanced Perioperative Care for Improving Outcomes After Colorectal Resection by Implementation of Best Practice for the Prevention of Anastomotic Leakage - Double Check Study: Protocol for a Multicenter Open-label Trial

TypeinterventionalSponsorAmsterdam UMC, location VUmcRan2021 to 2023Enrolled1,600ConditionsAnastomotic Leak Small Intestine, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum, Intraoperative AwarenessArmsEnhanced perioperative care protocol
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A de WitDepartment of Surgery, Amsterdam University Medical Centers, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
B T BootsmaDepartment of Surgery, Amsterdam University Medical Centers, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
D E HuismanDepartment of Surgery, Amsterdam University Medical Centers, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
G KazemierDepartment of Surgery, Amsterdam University Medical Centers, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
F DaamsDepartment of Surgery, Amsterdam University Medical Centers, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. f.daams@amsterdamumc.nl.
Taskforce Anastomotic Leakage

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPreoperative anemia is an important target in preventing colorectal anastomotic leakage (CAL). However, it is not consistently detected and corrected in patients undergoing colorectal surgery. This study aimed to evaluate the impact of early detection and correction of preoperative anemia on perioperative outcomes and CAL.

methodsThis was a prospective subanalysis of an international open-labeled trial, which implemented an enhanced care bundle to prevent CAL after elective colorectal surgeries. It introduced interventions for early detection and correction of preoperative anemia. Primary outcome was the incidence of preoperative anemia and the effect of early correction. Secondary outcomes included the impact on CAL, postoperative course, and mortality.

resultsThe study included 899 patients across eight European hospitals (September 2021-December 2023). Preoperative anemia was identified in 35.0% (n = 315) of participants, with 77.4% (n = 192) receiving iron therapy. Hemoglobin levels decreased in 4.2% (n = 13), remained stable in 45.8% (n = 143), and increased in 50.0% (n = 156) (p < 0.001). Perioperative hyperglycemia was more common among patients with anemia (7.8% versus 16.4%, p < 0.001). CAL occurred in 6.1% (n = 53) of patients. Anemia correction and changes in hemoglobin levels after iron treatment were not significantly associated with CAL, other complications, or mortality.

conclusionsEarly detection and correction of preoperative anemia is achievable. However, routine preoperative administration of iron alone, without concurrently optimizing other CAL risk factors, does not result in CAL prevention. Preoperative anemia indicates overall poor physiological fitness rather than being an isolated risk factor. TRIAL NUMBER: NCT05250882 (20-01-2022).

Indexed as

Anastomotic LeakAnemiaColorectal SurgeryPreoperative CareAgedEarly DiagnosisElective Surgical ProceduresEuropeFemaleHemoglobinsHumansIncidenceIronMaleMiddle AgedPreoperative PeriodHemoglobinsIronAnastomotic leakageAnemiaColorectal surgeryIron transfusion

Identifiers

PMID40186755
PMCPMC11972174

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Registered trials

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