Evidence map›Paper›PMID 40186735›Full record

ArticleUpdates in surgery2025

Vitamin D receptor: a possible biomarker for sporadic parathyroid adenoma?

Angeliki Chorti, Angeliki Cheva, Kassiani Boulogeorgou, Anthoula Chatzikyriakidou, Charoula Achilla, Despoina Tsalkatidou, Despoina Krokou, Sohail Bakkar, Papavramidis Theodossis

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Article in Updates in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angeliki Chorti1st Propaedeutic Department of Surgery, Faculty of Health Science, Medical School, AHEPA University Hospital, Aristotle University, St.Kiriakidi 1, 54636, Thessaloniki, Greece. angeliki.g.chorti@gmail.com.
Angeliki ChevaLaboratory of Pathology, Faculty of Health Science, Medical School, Aristotle University, Thessaloniki, Greece.
Kassiani BoulogeorgouLaboratory of Pathology, Faculty of Health Science, Medical School, Aristotle University, Thessaloniki, Greece.
Anthoula ChatzikyriakidouLaboratory of Medical Biology - Genetics, Faculty of Health Science, Medical School, Aristotle University, Thessaloniki, Greece.
Charoula AchillaLaboratory of Medical Biology - Genetics, Faculty of Health Science, Medical School, Aristotle University, Thessaloniki, Greece.
Despoina Tsalkatidou1st Propaedeutic Department of Surgery, Faculty of Health Science, Medical School, AHEPA University Hospital, Aristotle University, St.Kiriakidi 1, 54636, Thessaloniki, Greece.
Despoina Krokou1st Propaedeutic Department of Surgery, Faculty of Health Science, Medical School, AHEPA University Hospital, Aristotle University, St.Kiriakidi 1, 54636, Thessaloniki, Greece.
Sohail BakkarDepartment of General and Specialized Surgery, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Papavramidis Theodossis1st Propaedeutic Department of Surgery, Faculty of Health Science, Medical School, AHEPA University Hospital, Aristotle University, St.Kiriakidi 1, 54636, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parathyroid adenoma is the main cause of primary hyperparathyroidism. The genetic basis of the disease is still unclear. Vitamin D receptor (VDR) is involved in parathormone regulation. The aim of this study is to evaluate Vitamin D receptor expression in sporadic parathyroid adenoma. Fifty-one patients with parathyroid adenoma and 51 healthy volunteers were enrolled in the study and genetic and immunohistochemical studies were conducted. VDR polymorphism TaqI was correlated with parathyroid adenoma development, while VDR stained positive in immunohistochemical study. Our study suggests VDR as a major contributor to sporadic parathyroid adenoma formation in Greek population.

Indexed as

AdenomaBiomarkers, TumorParathyroid NeoplasmsReceptors, CalcitriolAdultAgedCase-Control StudiesFemaleHumansImmunohistochemistryMaleMiddle AgedPolymorphism, GeneticBiomarkers, TumorReceptors, CalcitriolVDR protein, humanBiomarkerGeneticsParathyroid adenomaParathyroid glandVitamin D receptor

Identifiers

PMID40186735
PMCPMC12263464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.