Evidence map›Paper›PMID 40186705›Full record

ArticleJournal of thrombosis and thrombolysis2025

The severity of ischemic stroke and risk of all-cause mortality in patients with atrial fibrillation on different oral anticoagulant treatments admitted to the emergency department.

Tommasa Vicario, Danilo Menichelli, Alfredo Paolo Mascolo, Marina Diomedi, Sara Cerretti, Francesco Marconi, Pasquale Pignatelli, Carla Paganelli, Daniele Pastori

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In one paragraph

Article in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tommasa Vicario *Emergency Department, Policlinico Tor Vergata Hospital, Rome, Italy.
Danilo Menichelli *Department of General Surgery and Surgical Specialties "Paride Stefanini", Sapienza University of Rome, Rome, Italy.
Alfredo Paolo MascoloStroke Center, Department of Systems Medicine, University Hospital of Rome 'Tor Vergata', Rome, Italy.
Marina DiomediStroke Center, Department of Systems Medicine, University Hospital of Rome 'Tor Vergata', Rome, Italy.
Sara CerrettiEmergency Department, M.G. Vannini Hospital, "Istituto delle Figlie di San Camillo", Rome, Italy.
Francesco MarconiDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00185, Italy.
Pasquale PignatelliDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00185, Italy.
Carla PaganelliEmergency Department, Policlinico Tor Vergata Hospital, Rome, Italy.
Daniele PastoriDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00185, Italy. daniele.pastori@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although direct oral anticoagulants (DOACs) are non-inferior to Vitamin K antagonists (VKA) in preventing ischemic stroke (IS) in atrial fibrillation (AF) patients, there are limited data regarding stroke severity and prognosis of patients admitted with IS during DOAC treatment. We performed a single center retrospective study including patients with AF on oral anticoagulants admitted to the Emergency Department for IS were included. The primary endpoint was to analyse the severity of stroke evaluated through NIHSS scale according to anticoagulant therapy. The secondary endpoint was 3-month all-cause mortality. A total of 106 AF patients were included, with a mean age of 81.3 ± 7.5 years. Overall, 54.7% were women and 61.3% on DOAC. The AF patients on DOAC were older, with no other clinical differences. Median NIHSS was 12 (Interquartile Range [IQR] 5-19). At multivariable logistic regression analysis DOAC use (compared to warfarin) was associated with lower risk of moderate-severe/severe stroke (NIHSS ≥ 16) (Odds Ratio [OR] 0.355, 95% confidence interval [95% CI] 0.127-0.995). Mechanical thrombectomy was strongly associated with higher severity of stroke (OR 6.113, 95%CI 2.186-17.099). During follow-up, 42 patients died. DOAC use inversely correlated with mortality risk (OR 0.323, 95%CI 0.127-0.822) after adjusting for CHA

Indexed as

AnticoagulantsAtrial FibrillationIschemic StrokeAdministration, OralAgedAged, 80 and overEmergency Service, HospitalFemaleHumansMaleRetrospective StudiesRisk FactorsSeverity of Illness IndexAnticoagulantsAtrial fibrillationDOACISIschemic strokeNIHSSSeverityVKA

Identifiers

PMID40186705
PMCPMC12043793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.