Evidence map›Paper›PMID 40186702›Full record

ArticleJournal of thrombosis and thrombolysis2025

Thrombin generation and clot lysis time to predict outcomes in patients undergoing transcatheter aortic valve implantation.

Aleksander Siniarski, Jakub Michal Zimodro, Aleksandra Gąsecka, Michał Łomiak, Marta Frydrych, Jadwiga Nessler, Grzegorz Gajos

Abstract read
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In one paragraph

Article in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aleksander SiniarskiDepartment of Coronary Artery Disease and Heart Failure, Faculty of Medicine, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
Jakub Michal Zimodro1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw, 02-097, Poland.
Aleksandra Gąsecka1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw, 02-097, Poland. aleksandra.gasecka@wum.edu.pl.
Michał Łomiak1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw, 02-097, Poland.
Marta Frydrych1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw, 02-097, Poland.
Jadwiga NesslerDepartment of Coronary Artery Disease and Heart Failure, Faculty of Medicine, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
Grzegorz GajosDepartment of Coronary Artery Disease and Heart Failure, Faculty of Medicine, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.

Funding

Jagiellonian University Medical College, Krakow, Poland N41/DBS/000711, N41/DBS/001221
6 · The paper itself

Abstract

Transcatheter aortic valve implantation (TAVI) is an established treatment method in patients with severe aortic stenosis at high surgical risk. TAVI might reduce thrombin generation and fibrin clot resistance to lysis. We aimed to evaluate the predictive value of thrombin generation and clot lysis time on TAVI outcomes. We screened 135 patients referred for TAVI. Thrombin generation (lag time, time to peak, peak thrombin concentration, and endogenous thrombin potential) and clot lysis time were assessed before TAVI and at hospital discharge. Major adverse cardiac and cerebrovascular events (MACCE) including all-cause death, cardiovascular death, myocardial infarction, stroke, transient ischemic attack, heart failure decompensation, and clinical valve thrombosis were assessed during 1-year follow-up. Among 70 patients who underwent TAVI, 14 (20%) experienced MACCE during the median follow-up of 361 days. Before TAVI, thrombin generation and clot lysis time were similar in patients with vs. without MACCE. Post-TAVI peak thrombin concentration was significantly lower in patients with MACCE (157.5 vs. 240.38 nM, p = 0.016), discriminated between those with and without MACCE (AUC: 0.773, p = 0.016), and was predictive for MACCE in both univariable (OR: 10.733, 95% CI: 1.197-96.283, p = 0.034) and multivariable (OR: 11.551, 95% CI: 1.104-120.828, p = 0.041) regression analyses. Pre-TAVI lag time was a predictor of MACCE in univariable regression analysis (OR: 5.304, 95% CI: 1.074-26.182, p = 0.041). Post-TAVI peak thrombin concentration and pre-TAVI lag time might potentially serve as novel predictors of MACCE in patients undergoing TAVI.

Indexed as

Aortic Valve StenosisFibrin Clot Lysis TimeThrombinTranscatheter Aortic Valve ReplacementAgedAged, 80 and overFemaleHumansMalePredictive Value of TestsThrombosisTreatment OutcomeThrombinAortic stenosisFibrin clotFibrinolysisThrombin generationTranscatheter aortic valve implantation

Identifiers

PMID40186702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.