Evidence map›Paper›PMID 40186653›Full record

ArticlePediatric radiology2025

Highly accelerated 4D flow MRI with respiratory compensation and cardiac view sharing: a cross-sectional study of flow in the great vessels of pediatric congenital heart disease.

Fatemeh Rastegar Jooybari, Christopher Huynh, Sharon Portnoy, Jonathan Voutsas, Diana Balmer-Minnes, Ankavipar Saprungruang, Shi-Joon Yoo, Christopher Z Lam, Christopher K Macgowan

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Article in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Canadian radiology: 2025 update.Japanese journal of radiology · 2025
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fatemeh Rastegar JooybariUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 1A1, Canada. fatemeh.rastegar@mail.utoronto.ca.
Christopher HuynhHospital for Sick Children, Toronto, Canada.
Sharon PortnoyHospital for Sick Children, Toronto, Canada.
Jonathan VoutsasQueen's University, Kingston, Canada.
Diana Balmer-MinnesHospital for Sick Children, Toronto, Canada.
Ankavipar SaprungruangHospital for Sick Children, Toronto, Canada.
Shi-Joon YooHospital for Sick Children, Toronto, Canada.
Christopher Z LamHospital for Sick Children, Toronto, Canada.
Christopher K MacgowanUniversity of Toronto, 27 King's College Cir, Toronto, ON, M5S 1A1, Canada.

Funding

Canadian Institutes for Health Research PJT-189980National Science and Engineering Research Council of Canada RGPIN-2019-06483
6 · The paper itself

Abstract

backgroundConventional four-dimensional (4D) flow magnetic resonance imaging (MRI) is limited by long scan times, particularly in pediatric congenital heart disease (CHD) patients.

objectiveThis study evaluates accelerated 4D flow MRI incorporating respiratory compensation and cardiac view sharing in healthy adults and pediatric CHD patients. MATERIALS AND

methodsSubjects underwent 5-min free-breathing protocol with a three-dimensional (3D) radial trajectory and compressed sensing reconstruction. The 4D flow MRI reconstruction pipeline was improved by respiratory soft-gating and cardiac view sharing. Flow in major thoracic vessels was compared with two-dimensional (2D) phase contrast MRI, the reference standard.

resultsFourteen pediatric CHD patients (median age: 13 years (interquartile range (IQR): 5)) and four healthy adult volunteers (median age: 26 years (IQR: 3)) were recruited. Soft-gating improved diaphragm sharpness and reduced respiratory-induced blur (image quality scores: healthy: 46.1 soft-gated vs. 47.2 non-gated; CHD: 47.8 soft-gated vs. 48.2 non-gated). View sharing reduced undersampling artifacts and enhanced the signal-to-noise ratio (SNR, healthy: +9.9%; CHD: +3.8%). In healthy adults, correlations with 2D phase contrast MRI were strong for mean flow (R

conclusionThe accelerated 4D flow MRI method provides robust flow quantification and visualization in pediatric CHD patients, strongly correlating with 2D phase contrast MRI and completing scans in 5 min for clinical use.

Indexed as

Heart Defects, CongenitalImaging, Three-DimensionalMagnetic Resonance AngiographyMagnetic Resonance ImagingRespiratory-Gated Imaging TechniquesAdolescentAdultChildCross-Sectional StudiesFemaleHumansImage Interpretation, Computer-AssistedMale4D flow magnetic resonance imagingCardiovascularCompressed sensingCongenital heart diseaseFlow quantificationsMagnetic resonance imagingPediatrics

Identifiers

PMID40186653

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.