Evidence map›Paper›PMID 40186643›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

A systematic review and meta-analysis of side effects influenced by non-surgical treatments in African cancer patients.

Omolola Salako, Muhammad Y Habeebu, Paul T Okediji, Adaorah F Enyi, Kehinde S Okunade, Gabriel T Fagbenro, Blossom A Maduafokwa, Oghenekome O Agha, Kamaldeen Abdulraheem, Matthew J Allsop

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Response comment to Veldi et al.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Article
  3. Article
  4. Comment on "A systematic review and meta‑analysis of side effects influenced by non‑surgical treatments in African cancer patients".Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Omolola SalakoDepartment of Radiation Biology, Radiotherapy & Radiodiagnosis, College of Medicine, University of Lagos, Lagos, Nigeria.
Muhammad Y HabeebuNSIA-LUTH Cancer Centre, Lagos, Nigeria.
Paul T OkedijiSynberg Research & Analytics, Abuja, Nigeria.
Adaorah F EnyiOncopadi Technologies Limited, Lagos, Nigeria.
Kehinde S OkunadeDepartment of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.
Gabriel T FagbenroSouth Dakota State University, Brookings, USA.
Blossom A MaduafokwaDepartment of Community Health, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria.
Oghenekome O AghaOncopadi Technologies Limited, Lagos, Nigeria.
Kamaldeen AbdulraheemDepartment of Community Health, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria. olasuraheem@gmail.com.
Matthew J AllsopAcademic Unit of Palliative Care, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer treatments such as chemotherapy immunotherapy and radiotherapy are associated with serious adverse effects that affect a patient's physiological functioning and physical appearance, contribute to financial toxicity, reduce quality of life, and increase the risk of treatment discontinuation. This systematic review aims to describe treatment-related side effects associated with non-surgical cancer treatment and clinical factors that influence the severity of side effects experienced among African cancer patients.

methodA systematic search of primary research studies reporting side effects of chemotherapy, radiotherapy, hormone therapy, targeted therapy, and immunotherapy among patients in African countries was undertaken across four databases (Medline (PubMed), ClinicalTrials.gov, Embase, and Cochrane Central Register of Controlled Trials).

resultsOf the 7870 identified articles, 51 eligible studies were included . Articles outlined side effects from chemotherapy (n = 31), radiotherapy (n = 6), chemoradiation (n = 9), chemotherapy and targeted therapy (n = 2), and chemotherapy, radiotherapy, and targeted therapy (n = 3). The most prevalent side effects reported were nausea and vomiting (chemotherapy), radiation dermatitis (radiotherapy), neutropenia, and anaemia (chemoradiation). Included studies reported an increased risk of side effects related to combined therapy (i.e., chemoradiation), type of chemotherapy, higher cumulative chemotherapy doses, more frequent treatment cycles, and the presence of comorbidities. Six studies indicated treatment discontinuation arising due to treatment-related side effects.

conclusionThe review highlights the need for cancer care providers to anticipate treatment-related side effects and mitigate them ahead of time, providing necessary prophylactic measures and treatment support.

Indexed as

Antineoplastic AgentsNeoplasmsAfricaHumansImmunotherapyQuality of LifeRadiotherapyAntineoplastic AgentsAdverse effectsAfricaCancer treatmentChemoradiationChemotherapyImmunotherapyRadiotherapySide effects

Identifiers

PMID40186643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.