Evidence map›Paper›PMID 40186439›Full record

Observational studyAmerican journal of hematology2025

Development of Polygenic Risk Score for Persistent Albuminuria in Children and Adults With Sickle Cell Anemia.

Rima S Zahr, Guolian Kang, Xu Zhang, Sara R Rashkin, Csaba P Kovesdy, Clifford Takemoto, Mitch Weiss, Jeffrey Lebensburger, Kenneth I Ataga, Santosh L Saraf

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rima S ZahrDepartment of Paediatric Nephrology and Hypertension, UTHSC, Memphis, Tennessee, USA.ORCID 0000-0002-3631-7195
Guolian KangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Xu ZhangDepartment of Haematology and Oncology, Sickle Cell Center, UIC, Chicago, Illinois, USA.ORCID 0000-0002-7732-1385
Sara R RashkinDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0001-5542-6891
Csaba P KovesdyDepartment of Nephrology, UTHSC, Memphis, Tennessee, USA.ORCID 0000-0002-8204-911X
Clifford TakemotoDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Mitch WeissDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0003-2460-3036
Jeffrey LebensburgerDepartment of Hematology, UAB, Birmingham, Alabama, USA.
Kenneth I AtagaUTHSC, Sickle Cell Center, Memphis, Tennessee, USA.ORCID 0000-0002-4501-9982
Santosh L SarafDepartment of Haematology and Oncology, Sickle Cell Center, UIC, Chicago, Illinois, USA.ORCID 0000-0002-8584-4194

Funding

Pathways of Cell-Free Hemoglobin in Sickle Cell NephropathyR01HL153161 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SARAF, SANTOSH · 2020 to 2024
$2.0M
Genetic modifiers of Sickle Cell Kidney DiseaseK23HL157554 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Rima Zahr · 2022 to 2026
$849k
Mentoring & Patient-Oriented Research in Sickle Cell-Related Kidney DiseaseK24HL177273 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Santosh Saraf · 2025 to 2026
$274k
NHLBI NIH HHS K23 HL157554NHLBI NIH HHS K23HL157554NHLBI NIH HHS K24 HL177273NHLBI NIH HHS R01 HL-153161NHLBI NIH HHS R01 HL153161
6 · The paper itself

Abstract

Albuminuria is associated with high-risk apolipoprotein-L1 variants (APOL1 G1/G2) in patients with sickle cell anemia (SCA). However, this gene variant does not account for all chronic kidney disease (CKD) risk. We hypothesized that we could develop a polygenic risk score (PRS) for CKD in SCA, combining APOL1 G1/G2 with other candidate genes that modify SCA severity and further stratify patients into risk categories based on this risk score. Variants in APOL1, HMOX1 (rs743811), BCL11A (rs1424407), and α-thalassemia (α

Indexed as

AlbuminuriaAnemia, Sickle CellMultifactorial InheritanceAdolescentAdultAllelesalpha-ThalassemiaApolipoprotein L1Cation Transport ProteinsChildChild, PreschoolFemaleGenetic Risk ScoreHeme Oxygenase-1HumansLongitudinal StudiesAPOL1 protein, humanApolipoprotein L1BCL11A protein, humanCation Transport ProteinsHeme Oxygenase-1HMOX1 protein, humanRepressor ProteinsalbuminuriaCKDgenetic risk scoresickle cell anemia

Identifiers

PMID40186439
PMCPMC12068958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.