ArticleEuropean journal of neurology2025
Reactive Pleocytosis After Repeated Lumbar Puncture-Implications for Clinical Practice.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Repeat Lumbar Puncture in Adults With Encephalitis: Patient Characteristics, Cerebrospinal Fluid Dynamics, and Diagnostic Yield.Open forum infectious diseases · 2026Article
- Two Cases of Oculomotor Nerve Palsy in Idiopathic Intracranial Hypertension and a Literature Review.Case reports in neurological medicine · 2026Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLumbar puncture (LP) is a routine clinical procedure and, in some cases, is repeatedly performed for diagnostic or therapeutic reasons. The impact of repeated LP on cerebrospinal fluid (CSF) findings is not clear.
objectiveTo investigate whether repeated LP is associated with reactive pleocytosis and disruption of blood-CSF barrier function and to determine the role of interval between repeated LP.
methodsPatients with non-inflammatory neurological disease (NIND) and at least two consecutive LP were included. Longitudinal changes in CSF white blood cell count (WBC), CSF total protein (TP), and CSF/serum albumin quotient (Q
resultsA total of 73 patients with a median age of 35 years (25th-75th percentile: 25-45) and a female predominance of 75% had second LP after 6 (3-19) days. Twenty (27%) patients developed pleocytosis with an increase of WBC count to 8/μl (6-15) with a maximum of 30/μl. Patients with pleocytosis had the follow-up LP significantly earlier than patients without pleocytosis, 3.5 (3-7) versus 7 (3-28) days. The majority of patients (90%) with CSF pleocytosis had the second LP within 10 days. Further repeated LP in a subgroup of patients revealed similar findings. CSF TP and Q
conclusionMild "reactive" CSF pleocytosis occurred in approximately one-third of patients after repeated LP, mostly when performed within 10 days.
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