Evidence map›Paper›PMID 40186378›Full record

ReviewImmunological reviews2025

Touching a Nerve: Neuroimmune Interactions in Asthma.

James M Kornfield, Hoyt Bright, Matthew G Drake

Abstract readReview
In one paragraph

Review in Immunological reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. The Role of the Nervous System in Lung Disease.Current neurology and neuroscience reports · 2026
    Review
  3. Review
  4. Article
  5. Optogenetic vagotomy inhibits reflex bronchoconstriction and cardiac chronotropy.American journal of respiratory cell and molecular biology · 2026
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James M KornfieldDivision of Pulmonary, Allergy, and Critical Care, Oregon Health and Science University, Portland, Oregon, USA.
Hoyt BrightDivision of Pulmonary, Allergy, and Critical Care, Oregon Health and Science University, Portland, Oregon, USA.
Matthew G DrakeDivision of Pulmonary, Allergy, and Critical Care, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0001-5476-0361

Funding

Multidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3M
Identifying mechanisms and reversibility of eosinophil-induced airway hyperinnervation in asthmaR01HL155623 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DRAKE, MATTHEW G. · 2021 to 2025
$3.3M
Mechanisms of tachykinergic nerve-mediated severe bronchoconstriction and inflammationR01HL171226 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Matthew G. Drake, ALLISON Deborah FRYER · 2024 to 2026
$2.3M
NHLBI NIH HHS HL155623NHLBI NIH HHS HL171226NHLBI NIH HHS R01 HL155623NHLBI NIH HHS R01 HL171226NHLBI NIH HHS T32 HL083808
6 · The paper itself

Abstract

Asthma is an inflammatory airway disease characterized by excessive bronchoconstriction and airway hyperresponsiveness. Airway nerves play a crucial role in regulating these processes. In asthma, interactions between inflammatory cells and nerves result in nerve dysfunction, which worsens airway function. This review discusses new insights regarding the role of airway nerves in healthy lungs and examines how communication between nerves and leukocytes, including eosinophils, mast cells, dendritic cells, and innate lymphoid cells, contributes to nerve dysfunction and the worsening of airway disease. Clinical implications and therapeutic opportunities presented by neuroimmune interactions are also addressed.

Indexed as

AsthmaLungNeuroimmunomodulationAnimalsEosinophilsHumansLeukocytesMast Cellsairwayasthmaeosinophilnerveneuroimmune interactions

Identifiers

PMID40186378
PMCPMC12121487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.