ArticleEuropean journal of medical research2025
Dihydroartemisinin inhibits lung cancer bone metastasis by modulating macrophage polarization.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The Therapeutic Potential of Dihydroartemisinin in Cancer Treatment.International journal of molecular sciences · 2026Review
- Dihydroartemisinin Unravels Dose-Dependent Transcriptomic Networks Orchestrating Ferroptosis and Metabolic Reprogramming in Colorectal Cancer.Current issues in molecular biology · 2026Article
- Anticancer properties of Artemisia species: mechanisms and experimental evidence.Molecular biology reports · 2026Review
- Review
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Authors and funding
6 authors.
Funding
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Abstract
The high metastasis rate of lung cancer contributes to its low 5-year survival rate. Bone metastasis is a common complication in advanced lung cancer, adversely affecting postoperative recovery. This study investigates the effects of DHA on macrophage polarization and its underlying mechanisms. In vitro, DHA was found to inhibit M2 polarization while promoting M1 polarization of macrophages, thereby reducing the invasion and migration of lung cancer cells. In vivo, DHA inhibited lung cancer growth and bone metastasis by modulating macrophage M1/M2 polarization in both lung cancer tissues and bone metastatic sites. In addition, through the CCL2/CCR2 pathway, DHA decreased macrophage recruitment and accumulation. These results suggest that DHA is effective in inhibiting lung cancer growth and bone metastasis, offering promising research and application prospects.
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