ArticleBMC surgery2025
Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective study.
Article in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Perioperative Anemia and Transfusion Management in Older Adults with Osteoporotic Hip Fractures: A Narrative Review of Current Evidence and Emerging Strategies.Clinical interventions in aging · 2026Review
- Preoperative hypocalcemia predicts postoperative complications in older orthopedic patients: A multicenter cohort study.PloS one · 2026Article
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6 authors.
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Abstract
backgroundSerum calcium is the critical coagulation factor in physiological coagulation, and hypocalcemia has been found to be associated with more blood loss in many diseases. The purpose of this study was to explore the effect of hypocalcemia on total blood loss (TBL) and blood transfusion in elderly patients with hip fracture. PATIENTS AND
methodsElderly patients with hip fracture undergoing surgery in our hospital were included in this study from January 2020 to May 2023. The demographic data, perioperative parameters, hemoglobin, hematocrit, and transfusion requirement were recorded and analyzed. Hypocalcemia was defined as an albumin-corrected calcium level of less than 2.15 mmol/L. TBL of each patient was calculated using the formulas of Nadler and Gross. Blood loss on the 1st and 5th postoperative days was calculated.
results682 elderly patients with hip fracture were included in the study. On admission, the prevalence of hypocalcemia was 40.47%. Both the TBL on the first day (714.91 ± 396.05 ml vs. 640.31 ± 398.83 ml, P = 0.016) and the fifth day (1035.87 ± 528.77 ml vs. 859.92 ± 434.99 ml, P < 0.001) after operation in the hypocalcemia group were higher than those in the normocalcemia group. The preoperative, postoperative and perioperative blood transfusion rates of hypocalcemia patients were higher than those of the normocalcemia group.
conclusionHypocalcemia was associated with increased TBL and blood transfusion in elderly patients with hip fracture during the perioperative period.
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