SynthesisBMC women's health2025
Exploring the role of cervicovaginal microbiota as risk factor for cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis : By.
Synthesis in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Bacterial co-infection as a catalyst in HPV-associated cervical carcinogenesis.Annals of medicine and surgery (2012) · 2026Article
- Global burden of cancer in women, 1990-2021: a systematic analysis from the GBD 2021 study.Frontiers in oncology · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
objectiveTo estimate the association between cervico-vaginal microbiota and cervical cancer in Sub-Saharan Africa. STUDY
designSystematic Review and Meta-Analysis.
methodThe databases, PubMed and African Journal Online (AJOL), as well as Google Scholar, were accessed. All primary studies (cross-sectional, cohort and case control) that reported cervical cancer, risk factors and cervico-vaginal microbiota in Sub-Saharan Africa, which were written in English language, were screened. Methodological and quality assessment of included studies was carried out using Joanna Briggs Institute (JBI) quality assessment tool. Random effects model meta-analysis was performed using MedCalc statistical software version 20.0.1 to evaluate the pooled prevalence of cervico-vaginal microbiota and prevalence was determined using the Freeman-Tukey double arcsine transformation. Heterogeneity between studies was assessed using the I-squared (I
resultsThe review involved screening of a total of 1,151 articles and 15 articles, which met the inclusion criteria, were finally used for the review and meta-analysis. Cervico-vaginal risk factors noted in our study comprised infection with high risk human papilloma virus (hrHPV), human Immune virus (HIV), Trichomonas vaginalis, Porphyromonas, Prevotella, and Anaeromonas. The pooled prevalence of HPV in the included studies was 40% (95% Confidence interval [CI]- 24%, 56%) and pooled prevalence of HIV as a risk factor was 19% (95% CI- 3%, 44%). For each individual meta-analysis, high heterogeneity was observed with I
conclusionThis systematic review and meta-analysis revealed that cervico-vaginal microbiota, such as Porphyromonas, Prevotella, and Trichomonas vaginalis, along with high-risk HPV and HIV infection, increase cervical cancer risk in Sub-Saharan Africa. To reduce this burden, integrating microbiota management, sexual health education and HPV vaccination, is crucial.
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