ArticleBiological trace element research2025
Molecular Changes Associated with Inflammation and Reproduction in Cadmium-Induced Testicular Toxicity: Mitigating Effect of Lactobacillus plantarum.
Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium (Cd) is a dangerous heavy metal that causes toxicity in humans and animals. Various protective agents are being investigated to ameliorate the toxic effect of Cd. Lactic acid bacteria are promising as a protective agent because of their ability to remove heavy metals from contaminated products. The aim of this study was to evaluate the effects of Lactobacillus plantarum on biomarkers associated with reproduction and inflammation in the testes of rats exposed to Cd. For the application, rats were randomly divided into four groups: Control group, Cd group, L. plantarum group, and combined group (Cd + L. plantarum). At the end of 21 days of oral administration, testicular tissues of the rats were removed and mRNA expression levels of genes associated with reproduction (Dazl, Amh, and Ddx4) and inflammation (Tnf-α, Il-6, Cox-2, Inos, Foxo1, Foxo3, and Nfkb) were determined. On the other hand, the amounts of NOS2/iNOS, 8-ohdg, and Tnfα were analyzed in the tissues. The mtDNA copy number was also investigated. Cd caused an increase in the expression level of inflammation-related genes, except Nfkb, and a decrease in the expression level of reproduction-related genes. It also increased the levels of TNF-α, iNOS, and 8-OHdG biomarkers and mtDNA copy number. However, L. plantarum treatment did not cause a significant change in these parameters. Moreover, L. plantarum exposure in combination with Cd attenuated the observed Cd-mediated molecular changes in testicular tissue. In conclusion, the findings suggest that L. plantarum administration may be beneficial against Cd-induced testicular toxicity and may be considered as a biological agent in the development of protective strategies against environmental pollutants with further studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.