Evidence map›Paper›PMID 40186045›Full record

ArticleJournal of bone and mineral metabolism2025

Supplemental magnesium gluconate recovers osteoblastic Wntless ablation-induced degenerative bone complications.

Govinda Bhattarai, Ju-Hyeon An, Shankar Rijal, Junil Lee, Junhyeok Kim, Sung-Ho Kook, Jeong-Chae Lee, Eui-Sic Cho

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Article in Journal of bone and mineral metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Govinda Bhattarai *Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju, 54896, South Korea.
Ju-Hyeon An *Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju, 54896, South Korea.
Shankar RijalCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju, 54896, South Korea.
Junil LeeCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju, 54896, South Korea.
Junhyeok KimCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju, 54896, South Korea.
Sung-Ho KookCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju, 54896, South Korea.
Jeong-Chae Lee *Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju, 54896, South Korea. jeongchae@jbnu.ac.kr.ORCID http://orcid.org/0000-0002-4340-7965
Eui-Sic Cho *Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju, 54896, South Korea. oasis@jbnu.ac.kr.

Funding

Ministry of Education, Science and Technology 2021R1A2C2006032Ministry of Education, Science and Technology RS-2023-00269830Ministry of Education, Science and Technology RS-2024-00338143
6 · The paper itself

Abstract

introductionAlthough numerous studies have highlighted the involvement of Wnt-mediated signaling in Mg ion-enhanced bone healing, whether Wnt-stimulated signaling is essential for the Mg ion-triggered bone repair and mass accrual is not yet completely understood. MATERIALS AND

methodsWe generated Wls

resultsOsteoblastic Wls ablation impaired bone mass accrual and bone healing along with age-related degenerative complications in bone marrow (BM) and BM cells. Oral supplementation of WT mice with MgG did not change natural bone mass accrual, but enhanced regenerative bone healing in femoral defects and the functionalities of BM cells. Supplemental MgG suppressed the Wls ablation-related bone loss and also stimulated new bone formation in the defects of MT mice. The MgG-induced beneficial effects in the MT mice were orchestrated with its potencies to ameliorate senescence, oxidative damage, and functional loss of BM and BM adherent cells, as well as to stimulate osteogenic activity.

conclusionThis study demonstrates that supplemental MgG is able to improve bone homeostatic maintenance by recovering age-related degenerative complications even at the lack of osteoblastic Wnt-stimulated signaling.

Indexed as

Bone DiseasesDietary SupplementsGluconatesOsteoblastsAnimalsBone RegenerationMiceOsteogenesisWnt Signaling PathwayGluconatesgluconic acidBone marrowBone mass accrualConditional knockoutMagnesium gluconateWntless

Identifiers

PMID40186045

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.