Evidence map›Paper›PMID 40186044›Full record

ArticleUpdates in surgery2025

Comparative analysis of surgical versus medical treatment in non-localized primary hyperparathyroidism: renal and skeletal outcomes.

Stefano Radellini, Antonella Scerrino, Pierina Richiusa, Gregorio Scerrino, Sergio Mazzola, Carla Giordano, David Taïeb, Nunzia Cinzia Paladino, Frédéric Sebag

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Updates in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefano RadelliniDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), Section of Endocrinology, University of Palermo, Palermo, Italy.
Antonella ScerrinoDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), Section of Endocrinology, University of Palermo, Palermo, Italy.
Pierina RichiusaDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), Section of Endocrinology, University of Palermo, Palermo, Italy.
Gregorio ScerrinoDepartment of Surgical Oncological and Oral Sciences, Unit of Endocrine Surgery, Policlinico "P. Giaccone", , University of Palermo, Via Liborio Giuffré 5, 90127, Palermo, Italy. gregorio.scerrino@tiscali.it.
Sergio MazzolaUnit of Clinical Epidemiology and Tumor Registry, Department of Laboratory Diagnostics, Policlinico "P. Giaccone", University of Palermo, Via L. Giuffré, 5, 90127, Palermo, Italy.
Carla GiordanoDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), Section of Endocrinology, University of Palermo, Palermo, Italy.
David TaïebDepartment of Nuclear Medicine, Timone Hospital, Aix-Marseille University, Rue Saint Pierre, 13005, Marseille, France.
Nunzia Cinzia PaladinoDepartment of General and Endocrine Surgery, Conception Hospital, Aix-Marseille University, 147, Boulevard Baille, 13005, Marseille, France.
Frédéric SebagDepartment of General and Endocrine Surgery, Conception Hospital, Aix-Marseille University, 147, Boulevard Baille, 13005, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary hyperparathyroidism (PHPT) presents diverse phenotypic variations. Few studies have investigated potential peculiarities of non-localized PHPT. This retrospective study aimed to compare renal and skeletal outcomes in patients with non-localized PHPT subjected to medical versus surgical treatment. Patients with non-localized PHPT from two European Tertiary Centers were divided into Group A (medical treatment, 42 patients) and Group B (Surgery, 45 patients). Biochemical markers, renal function, and bone mineral density (BMD) were assessed at baseline and 18-24 months post-treatment. At initial univariate analysis, Student's t test, Fisher's exact test, Wilcoxon test, and Friedman's non-parametric test were utilized. The two groups displayed significant differences in age and vitamin D levels. Group B exhibited notable post-operative reductions in serum calcium (p value < 0.00001, versus p < 0.001 for group A), PTH (p < 0.00001 versus 0.078 for group A), and calciuria (p < 0.05 versus 0.3657 for group A). Surgical intervention yielded significant improvements in BMD (group B: p < 0.0001; group A: p = 0.3359) at femoral and lumbar sites, with no post-treatment fractures in Group B, contrasting with Group A (4 new fractures). The GFR of group A showed a statistically non-significant change with a p value of 0.631. Conversely, for the group B, the GFR displayed a statistically significant change (p < 0.001.). Surgical intervention in non-localized PHPT showcased distinct advantages in normalizing calcemia and PTH levels and improving skeletal metabolism. Although few significant differences in renal function were observed post-surgery, the apparent advantage of group B should be interpreted taking into account the different average ages of the two cohorts.

Indexed as

Hyperparathyroidism, PrimaryParathyroidectomyAdultAgedBone DensityCalciumFemaleHumansKidneyMaleMiddle AgedParathyroid HormoneRetrospective StudiesTreatment OutcomeVitamin DCalciumParathyroid HormoneVitamin DBone mineral densityHypercalcemiaNon-localized primary hyperparathyroidismParathyroidectomyPrimary hyperparathyroidismRenal function

Identifiers

PMID40186044

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.