Evidence map›Paper›PMID 40186023›Full record

ArticleBiogerontology2025

Effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in SAMP8 mice.

Hanlin Jiang, Shota Inoue, Junpei Hatakeyama, Peng Liu, Tingrui Zhao, Yifan Zhang, Bin Liu, Chunxiao He, Hideki Moriyama

Abstract read
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In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanlin JiangDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Shota InoueDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Junpei HatakeyamaDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Peng LiuDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Tingrui ZhaoDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Yifan ZhangDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Bin LiuDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Chunxiao HeDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Hideki MoriyamaLife and Medical Sciences Area, Health Sciences Discipline, Kobe University, Tomogaoka 7-10-2, Suma-Ku, Kobe, Hyogo, 654-0142, Japan. morihide@harbor.kobe-u.ac.jp.

Funding

Japan Society for the Promotion of Science 19H04050
6 · The paper itself

Abstract

Skeletal muscle aging, characterized by progressive declines in muscle mass and strength, correlates with reduced quality of life and increased mortality. Resistance exercise is known to be critical for maintaining skeletal muscle health. This study investigated the effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in mice. Twenty-eight-week-old senescence-accelerated mouse prone 8 (SAMP8) mice were used as a model for muscle aging, with senescence-accelerated mouse resistant 1 (SAMR1) mice serving as healthy controls. The mice underwent a 12-week regimen of ladder-climbing training, a form of resistance exercise, performed three days per week. After the training, muscle strength and muscle weight were measured. Levels of the longevity proteins adenosine monophosphate-activated kinase (AMPK), mammalian target of rapamycin (mTOR), and sirtuin 1 (SIRT1) were assessed via western blotting, and telomere length was evaluated by qPCR. SAMP8 mice exhibited significantly lower muscle mass and strength than SAMR1 mice, while resistance exercise attenuated these deficits in SAMP8 mice. SAMP8 mice showed elevated AMPK phosphorylation and SIRT1 levels compared to SAMR1 mice; resistance exercise normalized AMPK phosphorylation levels to approximate those of SAMR1 mice. mTOR activity was significantly reduced in SAMP8 mice but tended to be restored by resistance exercise. Telomere length remained unchanged in SAMP8 mice after resistance exercise compared to their sedentary controls. In conclusion, aging reduces muscle function and disrupts levels of longevity proteins. Resistance exercise mitigates these effects by improving muscle function and restoring molecular balance.

Indexed as

AgingLongevityMuscle, SkeletalMuscle StrengthPhysical Conditioning, AnimalResistance TrainingTelomereTelomere HomeostasisAMP-Activated Protein KinasesAnimalsMaleMiceSirtuin 1TOR Serine-Threonine KinasesAMP-Activated Protein KinasesmTOR protein, mouseSirt1 protein, mouseSirtuin 1TOR Serine-Threonine KinasesLongevity proteinsMuscle agingResistance exerciseSarcopeniaTelomere length

Identifiers

PMID40186023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.