Evidence map›Paper›PMID 40185978›Full record

ArticleScientific reports2025

BMP2 expression in oral squamous cell carcinoma and its effects on SCC9 cell biological behavior.

Fuao Xing, Yimin Liu, Faming Tian, Xiaoli Hou, Qiangqiang Lian, Yunpeng Hu, Lei Xing, JingYuan Gao, Xinhao Fan

RetractedErratum issuedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Fuao XingNorth China University of Science and Technology, Tangshan, 063000, HeBei, China.
Yimin LiuNorth China University of Science and Technology, Tangshan, 063000, HeBei, China.
Faming TianNorth China University of Science and Technology, Tangshan, 063000, HeBei, China.
Xiaoli HouNorth China University of Science and Technology, Tangshan, 063000, HeBei, China.
Qiangqiang LianNorth China University of Science and Technology, Tangshan, 063000, HeBei, China.
Yunpeng HuSecond Hospital of Tangshan, Tangshan, 063000, HeBei, China.
Lei XingAffiliated Hospital of North China University of Science and Technology, Tangshan, 063000, HeBei, China.
JingYuan GaoAffiliated Hospital of North China University of Science and Technology, Tangshan, 063000, HeBei, China.
Xinhao FanNorth China University of Science and Technology, Tangshan, 063000, HeBei, China. ricky130701@163.com.

Funding

Cultivation Project of the Hebei Natural Science Foundation Precision Medicine Joint Fund. H2022209054Medical Science Research Project Plan of Hebei Province for the Year 2023 20231858Youth Talent Innovation Project of Kailuan (Group) Co., Ltd. 2023057
6 · The paper itself

Abstract

This study examined bone morphogenetic protein 2 (BMP2) expression in oral squamous cell carcinoma (OSCC) and its effects on the biological behavior of OSCC cells, along with potential underlying mechanisms. BMP2 expression in OSCC was analyzed using mRNA data from The Cancer Genome Atlas and Genomics Expression Omnibus Database (GEO). SCC9 cells were transfected in vitro with small interfering RNA targeting BMP2 (si-BMP2), a negative control sequence (si-NC), BMP2 plasmid, or empty plasmid (vector). After transfection, Cell Counting Kit-8 assays, colony formation, scratch wound healing, Transwell, flow cytometry, quantitative reverse transcription polymerase chain reaction, and Western blot analyses were conducted to assess changes in SCC9 cell behavior in response to altered BMP2 expression and to explore relevant signaling pathways.BMP2 upregulation promoted SCC9 cell proliferation, migration, and invasion; inhibited apoptosis; and activated the Smad1/5 and p38 signaling pathways. Conversely, BMP2 downregulation inhibited SCC9 cell proliferation, migration, and invasion; promoted apoptosis; and suppressed the Smad1/5 and p38 pathways. BMP2 is highly expressed in OSCC and may drive its progression through the BMP/Smad and p38 mitogen-activated protein kinase signaling pathways, indicating potential prognostic value and promise as a therapeutic target for small-molecule OSCC treatments.

Indexed as

Bone Morphogenetic Protein 2Carcinoma, Squamous CellGene Expression Regulation, NeoplasticMouth NeoplasmsApoptosisCell Line, TumorCell MovementCell ProliferationHumansSignal TransductionSmad ProteinsBMP2 protein, humanBone Morphogenetic Protein 2Smad ProteinsBiological behaviorBMP2MAPKOSCCSmad

Identifiers

PMID40185978
PMCPMC11971369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.