Evidence map›Paper›PMID 40185975›Full record

ArticleEMBO reports2025

CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis.

Zhongxue Feng, Lijun Wang, Yang Li, Yonggang Wei, Yueyue Zhou, Siying Wang, Xiaoqi Zhang, Chunling Jiang, Xuelian Liao, Yan Kang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. The Dual Role of Natural Killer Cells in the Septic Liver.Journal of inflammation research · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhongxue Feng *Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-7969-2905
Lijun Wang *Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-9595-1156
Yang Li *Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-5963-7178
Yonggang WeiDepartment of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yueyue ZhouFrontier Medical Center, Xin Chuan Road, Zhong He Street, 610212, Chengdu, Sichuan, China.
Siying WangInstitute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xiaoqi ZhangDepartment of Orthodontics, State Key laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Chunling JiangDepartment of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Xuelian LiaoDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yan KangDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. kangyan@scu.edu.cn.ORCID 0000-0002-5715-3900
Fei XiaoDepartment of Intensive Care Unit of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. icuxiaofei@scu.edu.cn.ORCID 0009-0004-5877-1956
Wei ZhangInstitute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. zhangwei197610@wchscu.edu.cn.ORCID 0000-0001-7588-7249

Funding

MOST | National Natural Science Foundation of China (NSFC) 82172142the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYGD18020/ZYJC18006The Natural Science Foundation of Sichuan Province 2024NSFSC1536the Sichuan Province Science and Technology Program 2023YFH0074
6 · The paper itself

Abstract

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. However, how this dysregulation occurs remains to be elucidated. In this study, we use single-cell RNA sequencing (scRNA-seq) and conventional RNA-seq to analyze the immune landscape of sepsis and observe that adaptive immunity is acutely and strongly suppressed. This systemic immunosuppression occurs not only in the peripheral blood but also in all other immune compartments, including the spleen, lymph nodes, and bone marrow. Clinical data show that these adaptive immunity-related genes may have the potential to be used to distinguish patients with sepsis from those with common infections. CD47 is found to play a pivotal role in this immunosuppression by inducing the production of amyloid-β (Aβ), which interacts with CD74 on B cells, leading to B-cell suppression and subsequent adaptive immunosuppression. Blocking CD47-Aβ signaling significantly reduces organ injury and improves the survival rate of septic mice by restoring phagocytic cell functions and alleviating B-cell suppression and adaptive immunosuppression.

Indexed as

Adaptive ImmunityAmyloid beta-PeptidesAntigens, Differentiation, B-LymphocyteCD47 AntigenHistocompatibility Antigens Class IIImmune ToleranceSepsisSignal TransductionAnimalsB-LymphocytesDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLAmyloid beta-PeptidesAntigens, Differentiation, B-LymphocyteCD47 AntigenCD47 protein, humanCd47 protein, mouseHistocompatibility Antigens Class IIinvariant chainAdaptive ImmunosuppressionAmyloid-β (Aβ)CD47SepsisSIRP

Identifiers

PMID40185975
PMCPMC12116991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.