Evidence map›Paper›PMID 40185953›Full record

ArticleJournal of assisted reproduction and genetics2025

Cryopreserved ovarian tissue autotransplantation in an acute myeloid leukaemia survivor following extensive minimal residual disease screening: first reported live birth in Europe.

Michelle Soares, Ingrid Segers, Michael De Brucker, Alessandra Camboni, Camille Hossay, Ileana Mateizel, Iebe De Quick, Ellen Van Moer, Dominik Selleslag, Steven Hellebaut and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michelle SoaresBrussels IVF, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium. Michelle.soares.be@gmail.com.ORCID http://orcid.org/0000-0002-8814-5276
Ingrid SegersBrussels IVF, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
Michael De BruckerBrussels IVF, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
Alessandra CamboniAnatomopathology Department, Cliniques Universitaires St-Luc, Brussels, Belgium.
Camille HossayPôle de Gynécologie, Institut de Recherche Expérimentale Et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.
Ileana MateizelBrussels IVF, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
Iebe De QuickBrussels IVF, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
Ellen Van MoerBrussels IVF, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
Dominik SelleslagHematology and Oncology Department, AZ Sint-Jan, Ruddershove 10, 8000, Brugge, Belgium.
Steven HellebautGynecology Department, O.L.V. Van Lourdes Hospital, Vijfseweg 150, 8790, Waregem, Belgium.
Marie-Madeleine DolmansPôle de Gynécologie, Institut de Recherche Expérimentale Et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.
Michel De VosBrussels IVF, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe report successful autotransplantation of ovarian tissue in a sterile acute myeloid leukaemia survivor after comprehensive minimal residual disease (MRD) screening.

methodsAt age 18, the patient underwent ovarian tissue cryopreservation while in complete remission prior to allogeneic stem cell transplantation. Premature ovarian failure and the wish to conceive led her to request transplantation of her cryopreserved ovarian tissue 12 years later. Extensive MRD screening of frozen-thawed biopsy specimens, including histology, immunohistochemistry, PCR and 6-month xenotransplantation to immunodeficient mice, was conducted before ovarian tissue transplantation (OTT).

resultsHistology and immunohistochemistry (MPO, p53, CD4, CD45) of thawed ovarian fragments showed no malignant cell contamination. Nested RT-PCR (MLL::AF9) was negative and the mouse grafted with ovarian tissue showed no disease after 6 months. The xenografted tissue was analyzed again (histology, immunohistochemistry and RT-PCR) and showed no contamination. Laparoscopic transplantation to the patient restored ovarian function after 4 months. Modified natural cycle IVF resulted in pregnancy. At 29 weeks, the patient had preterm premature rupture of membranes and delivered a healthy boy at 34.5 weeks. Three years post-transplantation, the patient remains disease-free.

conclusionsConcerns about malignant cell contamination limit cryopreserved OTT in leukemia survivors. This is the first reported European live birth in an acute myeloid leukemia survivor following frozen-thawed OTT. Safe OTT was achieved by retrieving ovarian tissue during complete remission and conducting thorough screening before transplantation. Obstetrical risks in leukemia survivors who had total body irradiation should also be thoroughly discussed during decision making before attempting motherhood.

Indexed as

CryopreservationLeukemia, Myeloid, AcuteNeoplasm, ResidualOvaryAdolescentAdultAnimalsCancer SurvivorsEuropeFemaleFertility PreservationHumansLive BirthMaleMicePregnancyFertility preservationLeukaemiaMinimal residual diseaseOvarian tissue cryopreservationOvarian tissue transplantation

Identifiers

PMID40185953
PMCPMC12167415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.