SynthesisOrthopadie (Heidelberg, Germany)2025
[Literature review on kyphoplasty as a treatment for osteoporotic fractures of the spine].
Synthesis in Orthopadie (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
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Abstract
backgroundOsteoeporotic vertebral fractures are one of the most common injuries in the elderly, with a prevalence of 10 to 15% in the population over 50 years of age. This type of fracture can be treated with minimally invasive surgery using kyphoplasty. The aim of this analysis is to show the advantages and disadvantages of treatment with kyphoplasty and to weigh up the different ways of performing this operation.
methodsThe systematic literature search included randomized controlled trials and clinical studies in the period from 01/09/2018-31/08/2024. The updated 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used for evaluation.
resultsA total of 16 studies from 4347 datasets were included. The most relevant outcome indices showed that the sole choice of surgical side (surgery from the symptom-dominant side) positively influences the VAS. In addition, the unilateral approach is recommended, as this is associated with a shorter operation time, as well as reduced cement volume and radiation exposure. Furthermore, bone density, different scores and certain biomarkers, such as NMID, beta-CTX and P1NP, can be positively influenced by the intravenous administration of zoledronic acid. PMMA bone cement loaded with gentamicin should be used as cement. Finally, drug treatment for osteoporosis and physical therapy are essential for postoperative recovery.
conclusionSurgical treatment of an osteoporotic vertebral fracture by means of kyphoplasty leads to improved results, even with the inclusion of additional therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.