Evidence map›Paper›PMID 40185895›Full record

ArticleScientific reports2025

Relationships between distance from the fovea to the disc and macular retinal layer thickness differ between normal and glaucomatous eyes.

Tomomi Higashide, Sachiko Udagawa, Makoto Araie, Hitomi Saito, Daisuke Takemoto, Kazuhisa Sugiyama, Goji Tomita, Atsuya Miki, Tsutomu Kikawa, Aiko Iwase and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tomomi HigashideDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, 920-8641, Ishikawa, Japan. eyetomo@med.kanazawa-u.ac.jp.
Sachiko UdagawaDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, 920-8641, Ishikawa, Japan.
Makoto AraieKanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan.
Hitomi SaitoDepartment of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Daisuke TakemotoDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, 920-8641, Ishikawa, Japan.
Kazuhisa SugiyamaDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, 920-8641, Ishikawa, Japan.
Goji TomitaDepartment of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.
Atsuya MikiDepartment of Myopia Control Research, Aichi Medical University Medical School, Nagakute, Japan.
Tsutomu KikawaR&D Division, Topcon Corporation, Tokyo, Japan.
Aiko IwaseTajimi Iwase Eye Clinic, Tajimi, Japan.
Toru NakazawaDepartment of Ophthalmology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Makoto AiharaDepartment of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kyoko Ohno-MatsuiDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Tae-Woo KimDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Christopher Kai Shun LeungDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Linda M ZangwillHamilton Glaucoma Center, Shiley Eye Institute, and the Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, and the Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.

Funding

Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Japan Society for the Promotion of Science 20K18368NEI NIH HHS EY027510NEI NIH HHS R01 EY027510
6 · The paper itself

Abstract

A multicenter cross-sectional study was conducted to investigate the magnification-corrected association between fovea-disc distance (FDD) and optical coherence tomography (OCT)-measured macular retinal layer thickness in eyes with and without primary open-angle glaucoma (POAG). A 12.0 × 9.0-mm-wide swept-source OCT scan, which includes both the macula and optic disc, was performed in 190 eyes from 124 healthy subjects (normal group) and 149 eyes from 117 POAG patients (POAG group). The FDD and thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell inner plexiform layer (GCIPL), and outer retina (OR, total retina minus (mRNFL plus GCIPL)) were measured and corrected for magnification effects. The mixed-effects models, accounting for potential confounding factors, revealed two significant associations between a longer FDD and retinal layer thickness: thinner mRNFL in the normal group (coefficients, -3.14, 95% confidence intervals (CI), -4.75 to -1.53; p = 0.0001) and thinner GCIPL in the POAG group (coefficients, -4.26; 95% CI, -6.85 to -1.67; p = 0.0013). The association between FDD and macular retinal layer thickness varies by retinal layer and the presence of POAG. FDD can significantly affect OCT-determined macular retinal layer thickness, especially GCIPL in POAG eyes and mRNFL in normal eyes.

Indexed as

Fovea CentralisGlaucoma, Open-AngleMacula LuteaOptic DiskRetinaAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNerve FibersRetinal Ganglion CellsTomography, Optical Coherence

Identifiers

PMID40185895
PMCPMC11971310

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.