ArticleScientific reports2025
Neck dissection improves the prognosis of patients with early-stage oral squamous cell carcinoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Use of Dual-Modality Antibody Imaging for Assessment of Lymph Node Metastases in Head and Neck Cancer.Theranostics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
For early-stage oral squamous cell carcinoma (OSCC), the primary treatment modality generally entails surgical resection. However, the role of neck dissection in early-stage OSCC remains controversial. The aim of this study was to evaluate the effect of neck dissection on the prognosis of patients with early-stage OSCC. We identified patients with early-stage OSCC from the Surveillance, Epidemiology, and End Results database spanning from 2004 to 2021. We collected demographic and clinical data, including age, sex, tumor site, marital status, race, residence, income, grade, records of radiotherapy and chemotherapy, neck management modality, survival time, disease-specific survival (DSS), and overall survival (OS). A retrospective cohort study design was employed to differentiate between the neck observation and neck dissection group. Kaplan-Meier survival analysis and Cox regression were utilized to evaluate the association between neck dissection and survival outcome. The study included 12,606 patients, of whom 5135 died (available for OS analysis), and 2477 died from OSCC (available for DSS analysis). Kaplan-Meier survival analysis revealed statistically differences between the observation and neck dissection group in OS (p < 0.0001) and DSS (p = 0.00067). Multivariate analysis confirmed that neck dissection was associated with improved survival, after adjusting for multiple factors such as, age, sex, tumor site, marital status, race, residence, income, grade, records of radiotherapy and chemotherapy, neck dissection was associated with a decreased risk of both DSS (hazard ratio [HR] = 0.73, 95% confidence interval [CI] = 0.66-0.8; p < 0.001) and OS (HR = 0.76, 95% CI = 0.71-0.81; p < 0.001). Patients with early-stage OSCC may derive significant clinical benefit from neck dissection; therefore, neck dissection is recommended for such patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.