Evidence map›Paper›PMID 40185768›Full record

ArticleNature communications2025

Proline-based tripodal cages with guest-adaptive features for capturing hydrophilic and amphiphilic fluoride substances.

Bo Huang, Sihao Li, Cong Pan, Fangzhou Li, Lukasz Wojtas, Qiao Qiao, Timothy H Tran, Laurent Calcul, Wenqi Liu, Chenfeng Ke and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bo HuangDepartment of Chemistry, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-6196-5373
Sihao LiDepartment of Chemistry, University of South Florida, Tampa, FL, USA.
Cong PanDepartment of Chemistry, University of South Florida, Tampa, FL, USA.
Fangzhou LiDepartment of Chemistry, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-2935-6329
Lukasz WojtasDepartment of Chemistry, University of South Florida, Tampa, FL, USA.
Qiao QiaoDepartment of Chemistry, University of South Florida, Tampa, FL, USA.
Timothy H TranChemical Biology Core, Moffitt Cancer Center, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-1342-7620
Laurent CalculDepartment of Chemistry, University of South Florida, Tampa, FL, USA.
Wenqi LiuDepartment of Chemistry, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-6408-0204
Chenfeng KeDepartment of Chemistry, Washington University, St. Louis, MO, USA. cke@wustl.edu.ORCID http://orcid.org/0000-0002-4689-8923
Jianfeng CaiDepartment of Chemistry, University of South Florida, Tampa, FL, USA. jianfengcai@usf.edu.ORCID http://orcid.org/0000-0003-3106-3306

Funding

Novel polymer biomaterials combating C. difficile infectionR01AI149852 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG, SUN, XINGMIN · 2019 to 2023
$1.9M
Antimicrobial agents derived from AApeptide biomaterialsR01AI152416 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2020 to 2024
$1.9M
DOE | SC | Basic Energy Sciences (BES) DE-SC0022267NIAID NIH HHS R01 AI149852NIAID NIH HHS R01 AI152416U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5RO1149852U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5RO1AI52416
6 · The paper itself

Abstract

Proteins exhibit remarkable molecular recognition by dynamically adjusting their conformations to selectively interact with ligands at specialized binding sites. To bind hydrated ligands, proteins leverage amino acid residues with similar water affinities as the substrate, minimizing the energy required to strip water molecules from the hydrophilic substrates. In synthetic receptor design, replicating this sophisticated adaptability remains a challenge, as most artificial receptors are optimized to bind desolvated substances. Here, we show that proline-based synthetic receptors can mimic the conformational dynamics of proteins to achieve selective binding of hydrophilic and amphiphilic fluoride substances in aqueous environments. This finding highlights the critical role of receptor flexibility and strategic hydrophilicity in enhancing ligand recognition and affinity in water. Moreover, it establishes a new framework for designing versatile synthetic receptors with tunable hydrophobicity and hydrophilicity profiles.

Indexed as

FluoridesProlineSurface-Active AgentsBinding SitesHydrophobic and Hydrophilic InteractionsLigandsProtein BindingWaterFluoridesLigandsProlineSurface-Active AgentsWater

Identifiers

PMID40185768
PMCPMC11971368

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.