ArticleNature communications2025
Whether or not to act is determined by distinct signals from motor thalamus and orbitofrontal cortex to secondary motor cortex.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations.Cell reports · 2026Article
- Widefield cortical activity and functional connectivity during motorized locomotion.Communications biology · 2026Article
- Thermodynamic Biomarkers of Neuroinflammation: Nanothermometry, Energy-Stress Dynamics, and Predictive Entropy in Glial-Vascular Networks.International journal of molecular sciences · 2025Review
- A cerebello-thalamo-cortical pathway transmits reward-based post-error signals for motor timing correction during learning in male mice.Nature communications · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
"To act or not to act" is a fundamental decision made in daily life. However, it is unknown how the relevant signals are transmitted to the secondary motor cortex (M2), which is the cortical origin of motor initiation. Here, we found that in a decision-making task in male mice, inputs from the thalamus to M2 positively regulated the action while inputs from the lateral part of the orbitofrontal cortex (LO) negatively regulated it. The motor thalamus that received the basal ganglia outputs transmitted action value-related signals to M2 regardless of whether the animal acted or not. By contrast, a large subpopulation of LO inputs showed decreased activity before and during the action, regardless of the action value. These results suggest that M2 integrates the positive signal of the action value from the motor thalamus with the negative action-biased signal from the LO to finally determine whether to act or not.
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