ArticleNature communications2025
Development of N-centered radical scavengers that enables photoredox-catalyzed transition-metal-free radical amination of alkyl pinacol boronates.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Copper-Catalyzed Amino Radical Transfer-Mediated Deborylation for Chiral Ester Synthesis.Angewandte Chemie (International ed. in English) · 2026Article
- Selective electrochemical methanol to formate conversion via direct CHO hydroxylation on PtNature communications · 2026Article
- Stable BFAngewandte Chemie (International ed. in English) · 2026Article
- Overcoming limitations in Chan-Lam amination with alkylboronic esters via aminyl radical substitution.Nature communications · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
In recent years, amination of alkylboronates through ionic copper catalysis or boron-ate complex 1,2-metalation has been well established, but complementary radical processes remain less studied before. Herein, based on rational design, we develop several imine-type N-centered radical scavengers and apply them to the radical amination of alkylboronates. The reaction proceeds under mild photoredox-catalyzed transition-metal-free conditions and features excellent functional group tolerance. It also enables the preparation of a range of medicinally valuable amine derivatives from complex natural products. Further application of this reagent in C-H amination, deoxygenative amination, decarboxylative amination and three component trifluoromethylative/sulfonylative aminations are also realized. Further mechanistic studies and DFT calculations are conducted to provide detailed evidence for the mechanism.
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Registered trials
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