ArticleNature communications2025
Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression.Molecular psychiatry · 2026Article
- A personalized map of where, when, and how to stimulate the brain to elicit controlled responses.bioRxiv : the preprint server for biology · 2026Article
- Cerebrovascular Imaging-to-Graph Reconstruction for Individualized Digital Twin Brains.bioRxiv : the preprint server for biology · 2026Article
- How Thalamo-Cortical Loops Modulate Cortico-Cortical Evoked Potentials?Brain topography · 2026Article
- Developmental disinhibition gates language lateralization in childhood.Nature communications · 2026Article
- The synaptic triad in depression: how stress-related pathways converge on BDNF, NMDA receptor, and MMP-9.Pharmacological reports : PR · 2026Review
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus.BMC medicine · 2026Article
- Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder.Biological psychiatry global open science · 2026Article
- The development of aperiodic neural activity in the human brain.Nature human behaviour · 2025Article
- cuBNM: GPU-Accelerated Brain Network Modeling.bioRxiv : the preprint server for biology · 2025Article
- Altered cortical excitability in tuberous sclerosis and the effect of mTOR inhibitors: An intracranial electrical stimulation study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Associations between neuronavigated rTMS-mediated functional connectome plasticity and neurotransmitter receptors in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
13 authors.
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Abstract
The human brain exhibits a modular and hierarchical structure, spanning low-order sensorimotor to high-order cognitive/affective systems. What is the mechanistic significance of this organization for brain dynamics and information processing properties? We investigated this question using rare simultaneous multimodal electrophysiology (stereotactic and scalp electroencephalography - EEG) recordings in 36 patients with drug-resistant focal epilepsy during presurgical intracerebral electrical stimulation (iES) (323 stimulation sessions). Our analyses revealed an anatomical gradient of excitability across the cortex, with stronger iES-evoked EEG responses in high-order compared to low-order regions. Mathematical modeling further showed that this variation in excitability levels results from a differential dependence on recurrent feedback from non-stimulated regions across the anatomical hierarchy, and could be extinguished by suppressing those connections in-silico. High-order brain regions/networks thus show an activity pattern characterized by more inter-network functional integration than low-order ones, which manifests as a spatial gradient of excitability that is emergent from, and causally dependent on, the underlying hierarchical network structure. These findings offer new insights into how hierarchical brain organization influences cognitive functions and could inform strategies for targeted neuromodulation therapies.
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