Evidence map›Paper›PMID 40185607›Full record

ArticleJACC. Case reports2025

Cardiac Amyloidosis With Right Atrial Appendage Thrombus Detected After Left Atrial Appendage Occlusion.

Kenji Nakano, Masato Fukunaga, Akihiro Isotani, Norihisa Miyawaki, Miho Nakamura, Toru Morofuji, Kenichi Ishizu, Masaomi Hayashi, Shinichi Shirai, Kenji Ando

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kenji NakanoDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Masato FukunagaDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan. Electronic address: masato_f0728@yahoo.co.jp.
Akihiro IsotaniDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Norihisa MiyawakiDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Miho NakamuraDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Toru MorofujiDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Kenichi IshizuDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Masaomi HayashiDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Shinichi ShiraiDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Kenji AndoDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial appendage occlusion (LAAO) is a valuable alternative therapy to anticoagulants for stroke prevention, and a representative study has demonstrated a high rate of anticoagulant discontinuation after LAAO. CASE SUMMARY: LAAO was performed on an 88-year-old woman with cardiac amyloidosis (CA). Although anticoagulant therapy was discontinued after LAAO, a follow-up image showed a thrombus in the right atrial appendage (RAA) incidentally. Anticoagulation was resumed, and no clinical events were detected during a 1-year follow-up. DISCUSSION: Although LAAO is an effective treatment for stroke prevention in patients with CA, this condition is associated with an increased risk of intracardiac thrombus. Therefore, discontinuation of anticoagulant therapy after LAAO should be approached by keeping in mind the possibility of RAA thrombus. TAKE-HOME MESSAGES: LAAO can be effective in CA, yet anticoagulation discontinuation must be individualized, keeping in mind the possibility of RAA thrombus in high-risk patients.

Indexed as

atrial fibrillationcardiac amyloidosisleft atrial appendage occlusion

Identifiers

PMID40185607
PMCPMC12046812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.