ArticleOpen heart2025
Diagnostic pathways, cardiac manifestations and outcomes in light chain amyloidosis: analysis of a US claims database.
Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- American Society of Hematology 2026 guidelines on diagnosis of light chain amyloidosis.Blood advances · 2026Guideline
- A Multicenter National Study of AL Amyloidosis in China: Insights Into Real-World Diagnosis, Treatment, and Prognosis.American journal of hematology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPatients with light chain (AL) amyloidosis, a rare life-threatening disease, often go through a lengthy diagnostic journey. We qualitatively and quantitatively characterised the diagnostic pathway and the impact of delayed diagnosis on health outcomes among patients with AL amyloidosis.
methodsWe conducted a retrospective cohort analysis of adults (age ≥18 years) with ≥2 AL amyloidosis diagnoses (index date: first diagnosis date) using the IQVIA PharMetrics Plus US claims data from 1 January 2016 to 31 December 2022. We stratified patients based on time from first cardiovascular (CV) manifestation onset to diagnosis. Patients were categorised as having a delayed diagnosis if the first CV manifestation occurred >1 year prior to diagnosis, and patients were categorised as without a delayed diagnosis if the first CV manifestation occurred <1 year prior to diagnosis.
resultsOur study included 470 patients (mean age 61.8 years, 60% males). In the 24 months before diagnosis, CV manifestations occurred in 86% of patients and renal manifestations in 74%. Patients most frequently visited on average four different cardiologists. Patients were most frequently diagnosed by haematologists/oncologists (49.8%). Patients with a delayed diagnosis (179/470, 38.1%) were twice as likely as those without a delayed diagnosis to have CV-related emergency room visits (adjusted OR: 1.98; 95% CI: 1.21 to 3.24; p<0.010). Patients with a delayed diagnosis were one and a half times more likely than those without a delayed diagnosis to have CV-related inpatient hospitalisations (adjusted OR: 1.65; 95% CI: 1.1 to 2.46; p=0.020).
conclusionsThis claims database study suggests that patients with delayed diagnosis experienced more CV-related emergency room visits and inpatient hospitalisations, underscoring the need for timely diagnosis of AL amyloidosis and the role of cardiologists in the diagnostic pathway.
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