Evidence map›Paper›PMID 40185230›Full record

ArticleThe Journal of biological chemistry2025

Tissue inhibitor of metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis.

Yuliang Rao, Qi Pan, Siyu Liu, Shunheng Yao, Lei Li, Jianyan Yan, Lifen Chen, Li Xu, Han Yan, Aicui Ma and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuliang RaoSchool of Pharmacy, School of Basic Medical Sciences, Fudan University, Shanghai, China; National Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Qi PanNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Siyu LiuNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Shunheng YaoNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Lei LiNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Jianyan YanNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Lifen ChenNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Li XuNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Han YanNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Aicui MaNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Fen WangNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Xiaoyan MaoNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Zhonghui WangNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Junfang ZhangNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China.
Jun GuoNational Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China. Electronic address: june_guo@163.com.
Zuyue SunSchool of Pharmacy, School of Basic Medical Sciences, Fudan University, Shanghai, China; National Evaluation Centre for the Toxicology of Fertility Regulating Drug, Shanghai Institute for Bio-medical and Pharmaceutical Technologies (SIBPT), Shanghai, China; NHC Key Laboratory of Reproduction Regulation, Shanghai, China; Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, China. Electronic address: sunzy64@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue inhibitor of metalloproteinase 1 (TIMP1) has been implicated in prostate cancer (PCa) metastasis. In this study, PC-3M-2B4 cells with TIMP1 knockdown (PC-3M-2B4-shTIMP1) or overexpression (PC-3M-2B4-TIMP1) were generated, and an inverse correlation was found between TIMP1 expression and cell migration and invasion, which was confirmed in vitro and in vivo. Differential TIMP1 expression was accompanied by variations in the expression of the ferroptosis-related proteins, glutathione peroxidase 4 (GPX4), transferrin receptor, transferrin, glutamine cysteine ligase catalytic subunit, and glutamine cysteine ligase modifier subunit. In comparison with TIMP1-overexpressing cells, TIMP1-knockdown cells demonstrated a 12.3% decrease in Fe

Indexed as

FerroptosisProstatic NeoplasmsTissue Inhibitor of Metalloproteinase-1AnimalsCell Line, TumorCell MovementGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudeNeoplasm MetastasisPhospholipid Hydroperoxide Glutathione PeroxidaseReceptors, TransferrinPhospholipid Hydroperoxide Glutathione PeroxidaseReceptors, TransferrinTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1ferroptosisGPX4metastasisprostate cancerTIMP1

Identifiers

PMID40185230
PMCPMC12059338

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.