Evidence map›Paper›PMID 40185101›Full record

ArticleCell2025

Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens.

Patrick Fernandes Rodrigues, Shitong Wu, Tihana Trsan, Santosh K Panda, José Luís Fachi, Yizhou Liu, Siling Du, Sarah de Oliveira, Alina Ulezko Antonova, Darya Khantakova and 7 more

Abstract read
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Review
  3. Intestinal uptake regulates T cell responses to dietary antigens.bioRxiv : the preprint server for biology · 2026
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Patrick Fernandes RodriguesDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Shitong WuDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Tihana TrsanDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Santosh K PandaDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
José Luís FachiDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Yizhou LiuDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Siling DuDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Sarah de OliveiraDepartment of Genetics and Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.
Alina Ulezko AntonovaDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Darya KhantakovaDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Raki SudanDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Pritesh DesaiDepartment of Medicine, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Michael S DiamondDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA; Department of Medicine, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Stephen K AndersonBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA. Electronic address: mcolonna@wustl.edu.

Funding

Pediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8M
CIS-REGULATORY CIRCUITS FOR ILC FUNCTION AND PLASTICITYR01AI134035 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Eugene M Oltz · 2018 to 2026
$4.8M
Mucosal Immune Defense Mechanisms of the Urinary BladderR01DK132327 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, SCOTT J. HULTGREN · 2023 to 2026
$2.5M
MICROBIOTA-DEPENDENT CONTROL OF CLOSTRIDIUM DIFFICILE: THE ROLE OF ACETATE AND IL-22 BINDING PROTEINR01DK126969 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2021 to 2024
$1.6M
Plasticity of Innate Lymphoid Cells: Mechanisms and Biological ImpactR01DK124699 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2020 to 2023
$1.4M
NIAID NIH HHS R01 AI134035NIDDK NIH HHS R01 DK124699NIDDK NIH HHS R01 DK126969NIDDK NIH HHS R01 DK132327NIDDK NIH HHS T32 DK077653
6 · The paper itself

Abstract

The intestinal immune system maintains tolerance to harmless food proteins and gut microbiota through peripherally derived RORγt

Indexed as

AntigensDendritic CellsNuclear Receptor Subfamily 1, Group F, Member 3T-Lymphocytes, RegulatoryAnimalsFood HypersensitivityImmune ToleranceMiceMice, Inbred C57BLTh2 CellsAntigensNuclear Receptor Subfamily 1, Group F, Member 3Rorc protein, mouseDCdendritic cellsILCoral tolerancePrdm16pTregRorcRorγtTh2Thetis cells

Identifiers

PMID40185101
PMCPMC12085292

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.