Evidence map›Paper›PMID 40185011›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids2025

Fatty acid synthase global inducible knockout does not alter brain fatty acid concentrations but attenuates cholesterol synthesis in the adult mouse.

Drew R Seeger, Peddanna Kotha, Svetlana A Golovko, Eric J Murphy, Mikhail Y Golovko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Drew R SeegerDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202-9037, United States.
Peddanna KothaDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202-9037, United States.
Svetlana A GolovkoDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202-9037, United States.
Eric J MurphyDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202-9037, United States.
Mikhail Y GolovkoDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202-9037, United States. Electronic address: mikhail.golovko@und.edu.

Funding

Validation of Adenylosuccinate as a Novel Endogenous Pro-Angiogenic Factor in the BrainR01NS119279 · NINDS · UNIVERSITY OF NORTH DAKOTA · PI GOLOVKO, MIKHAIL Y · 2021 to 2025
$2.7M
Neuronal-specific fatty acid synthesis activation as protective mechanism under hypoxiaR21NS109856 · NINDS · UNIVERSITY OF NORTH DAKOTA · PI GOLOVKO, MIKHAIL Y · 2018 to 2019
$382k
NINDS NIH HHS R01 NS119279NINDS NIH HHS R21 NS109856
6 · The paper itself

Abstract

Fatty acid (FA) de novo synthesis, also called de novo lipogenesis (DNL), has a central role in peripheral energy storage and provides structural components for lipid membranes. However, less is known regarding its contribution to brain FA homeostasis. DNL is catalyzed by fatty acid synthase (FAS), which is a multifunctional enzyme expressed in all mammalian tissues. In the present study, we addressed, for the first time, the effect of FAS gene global conditional inducible knockout (Fasn KO) on the adult brain FA concentrations and lipid metabolism. We achieved a 67 % reduction in the brain FAS protein levels, with a significant reduction in total FA synthesis measured by

Indexed as

BrainCholesterolFatty AcidsFatty Acid SynthasesFatty Acid Synthase, Type IAnimalsLipid MetabolismLipogenesisMaleMiceMice, Inbred C57BLMice, KnockoutCholesterolFasn protein, mouseFatty AcidsFatty Acid SynthasesFatty Acid Synthase, Type IBrainCholesterolFatty acidFatty acid synthaseKnockoutPPARSynthesis

Identifiers

PMID40185011
PMCPMC12146051

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.