Evidence map›Paper›PMID 40184896›Full record

ReviewPediatric neurology2025

Impaired Cerebral Autoregulation in Children.

Carlos Castillo-Pinto, Priscilla Yu, Mark S Wainwright, Matthew P Kirschen

Abstract readReview
In one paragraph

Review in Pediatric neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carlos Castillo-PintoDivision of Pediatric Neurology, Seattle Children's Hospital, University of Washington, Seattle, Washington. Electronic address: carlos.castillopinto@seattlechildrens.org.
Priscilla YuDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Mark S WainwrightDivision of Pediatric Neurology, Seattle Children's Hospital, University of Washington, Seattle, Washington.
Matthew P KirschenDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Funding

Cerebral autoregulation and MRI measures of brain injury after pediatric-post cardiac arrestK23NS116120 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI KIRSCHEN, MATTHEW P · 2021 to 2025
$966k
NINDS NIH HHS K23 NS116120
6 · The paper itself

Abstract

Managing acute brain injury involves protecting the brain from secondary injury by addressing the mismatch between metabolic demand and cerebral perfusion. Observational studies have associated impaired cerebral autoregulation, a physiological process governing the regulation of cerebral blood flow, with unfavorable neurological outcomes in both pediatric and adult populations. We review the pathophysiology of cerebral autoregulation and discuss methods for assessing and monitoring it in children after acquired brain injury. We also examine the current research investigating the relationship between impaired cerebral autoregulation and outcomes following traumatic brain injury, cardiac arrest, cardiopulmonary bypass, and extracorporeal membrane oxygenation. Furthermore, we outline potential areas for future research in cerebral autoregulation and its clinical implications for pediatric patients with brain injuries.

Indexed as

BrainBrain InjuriesCerebrovascular CirculationHomeostasisChildHumansCardiac arrestCerebral autoregulationECMOPediatricsTraumatic brain injury

Identifiers

PMID40184896
PMCPMC12118516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.