ArticleMolecular pharmacology2025
The neuroprotective γ-hydroxybutyrate analog 3-hydroxycyclopent-1-enecarboxylic acid does not directly affect CaMKIIα autophosphorylation at T286 or binding to GluN2B.
Carolyn Nicole Brown, Rachel E Blaine, Chase Madison Barker, Steven J Coultrap, Karl Ulrich Bayer
Abstract read
In one paragraphArticle in Molecular pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Carolyn Nicole BrownDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Rachel E BlaineDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Chase Madison BarkerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Steven J CoultrapDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Karl Ulrich BayerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Electronic address: ulli.bayer@cuanschutz.edu.
Funding
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1MPostsynaptic kinase/phosphatase networks in amyloid beta-induced synaptic dysfunctionR01NS110383 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MARK L DELL'ACQUA, Matthew J Kennedy · 2018 to 2026
$5.2MCaMKII substrate-selection in opposing forms of synaptic plasticityR01NS081248 · NINDS · UNIVERSITY OF COLORADO DENVER · PI K. Ulrich Bayer · 2013 to 2026
$4.9MCaMKII nitrosylation in the age-related decline of synaptic plasticityR01AG067713 · NIA · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH · 2020 to 2024
$2.7MCaMKII in global cerebral ischemia: mechanisms and therapeutic interventionR01NS118786 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2021 to 2025
$1.9MMolecular computation by the CaMKII holoenzymeF31NS129254 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BROWN, CAROLYN NICOLE · 2022 to 2024
$112kNIH HHS F31 NS129254NIH HHS R01 AG067713NIH HHS T32 GM007635NINDS NIH HHS R01 NS081248NINDS NIH HHS R01 NS110383NINDS NIH HHS R01 NS118786
6 · The paper itselfAbstract
Indexed as
Calcium-Calmodulin-Dependent Protein Kinase Type 2CyclopentanesNeuroprotective AgentsReceptors, N-Methyl-D-AspartateAnimalsHEK293 CellsHippocampusHumansLong-Term PotentiationNeuronsPhosphorylationProtein BindingRatsCalcium-Calmodulin-Dependent Protein Kinase Type 2CyclopentanesNeuroprotective AgentsNR2B NMDA receptorReceptors, N-Methyl-D-AspartateCaMKIICerebral ischemiaGluN2BLTPSynapse
Identifiers
PMID40184780
PMCPMC13095473
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