ArticleNeurology2025
Neuroimaging Correlates of Traumatic Brain Injury in an Older Community-Dwelling Population: The Atherosclerosis Risk in Communities Study.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
objectivesNeuroimaging correlates of remote traumatic brain injury (TBI) are not well understood. Our objective was to examine associations of TBI with brain MRI markers of degeneration and vascular disease.
methodsWe performed a cross-sectional analysis using data from a subset of participants who underwent a 3T brain MRI during the fifth Atherosclerosis Risk in Communities Study visit in 2011-2013. Prior TBI and age at first TBI (<18 years, 18-65 years, >65 years) was defined using self-report and International Classification of Diseases, Ninth Edition code data. We examined the following brain MRI metrics: presence of infarcts and microhemorrhages, white matter hyperintensity (WMH) volume, and the distribution of the number of regions of interest (ROIs) below a
resultsA total of 1,642 participants were included (mean age 76.8 ± 5.32 years, 61.0% female, 28.3% self-reported Black race, and 25.5% with a history of TBI [median time between first TBI and MRI: 38.2 years]). There was no evidence of differences in vascular imaging findings by overall TBI status, but individuals who sustained their first TBI at age <18 years had higher WMH volume (adjusted β = 0.22 mm DISCUSSION: In this community-dwelling cohort of older adults, TBI was associated with smaller brain volumes, lower cortical thickness, lower FA, and higher MD. Further work is needed in the chronic postinjury period to elucidate the mechanisms underlying the observed structural changes after TBI.
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