Evidence map›Paper›PMID 40184573›Full record

ArticleJCO oncology practice2025

Guidelines, Counseling Practices, and Fertility Preservation Options for Childhood Cancer Patients in the Nordic-Baltic Region.

Monika Grubliauskaite, Zivile Gudleviciene, Irma C Oskam, Babak Asadi-Azarbaijani, Kirsi Jahnukainen

Abstract read
In one paragraph

Article in JCO oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monika GrubliauskaiteLife Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID 0000-0002-1882-8637
Zivile GudlevicieneDepartment of Biobank, National Cancer Institute, Vilnius, Lithuania.
Irma C OskamThe Livestock Production Research Centre, Norwegian University of Life Sciences, Ås, Norway.
Babak Asadi-AzarbaijaniFaculty of Health Sciences, VID Specialized University, Oslo, Norway.ORCID 0000-0003-0971-3560
Kirsi JahnukainenDepartment of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDespite new medicine and treatment options, fertility is impaired for many childhood cancer survivors after gonadotoxic treatment. In the current study, we compiled an overview on the state of fertility preservation (FP) care and limitations for childhood cancer patients throughout the Nordic-Baltic region. MATERIALS AND

methodsIn partnership with the Nordic Society of Pediatric Hematology and Oncology, an anonymous survey was conducted among 23 major pediatric oncology centers in Nordic and Baltic countries. The survey featured 22 multiple-choice and open-ended questions that provided insights into guidelines, available FP options, clinical indications, and counseling.

resultsThe response rate to the questionnaire was 74% (17 of 23 pediatric oncology centers). The survey revealed that only 65% of the centers have national guidelines on FP at the time. Although all centers offer counseling before treatment by oncologists (88%) or gynecologists (65%), 76% of the centers provide it only to those fulfill inclusion criteria. Additionally, counseling is unavailable for some patients because of age (35%), communication issues (29%), or lack of time (24%). Predominantly, sperm cryopreservation is offered across all centers for pubertal boys, while testicular tissue cryopreservation is provided at 41% of pediatric oncology centers for prepubertal boys. Oocyte cryopreservation is offered to pubertal girls at 88% of the centers, and ovarian tissue cryopreservation is offered to prepubertal and pubertal girls at 82% of the questioned centers.

conclusionThe survey highlights the implementation of FP services status in the Nordic and Baltic countries. However, standardizing FP indications and disseminating guidelines widely is crucial to reduce clinical variability. Addressing issues such as inconsistent counseling, limited collaboration, and unclear risk stratification can drive further improvements.

Indexed as

CounselingFertility PreservationNeoplasmsPractice Guidelines as TopicAdolescentBaltic StatesChildFemaleHumansMaleScandinavian and Nordic CountriesSurveys and Questionnaires

Identifiers

PMID40184573
PMCPMC12622272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.