Evidence map›Paper›PMID 40184462›Full record

ArticleScience advances2025

Diagnosing Parkinson's disease via behavioral biometrics of keystroke dynamics.

Trinny Tat, Guorui Chen, Jing Xu, Xun Zhao, Yunsheng Fang, Jun Chen

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Advances in Wearable Bioimaging.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  3. Article
  4. Article
  5. Artificial Intelligence-Driven Soft Bioelectronics for Self-Powered Respiration Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Trinny TatDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-9068-8325
Guorui ChenDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8387-5723
Jing XuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-3157-6902
Xun ZhaoDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-5543-0081
Yunsheng FangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-2213-0167
Jun ChenDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-3439-0495

Funding

Caltech/UCLA Individualized Theranostic Engineering to Advance Metabolic System (iTEAM)T32EB027629 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Dino Di Carlo, Azita Emami · 2020 to 2026
$2.0M
A soft magnetoelastic microneedle patch for rapid skin cancer screeningR01CA287326 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jun Chen · 2024 to 2026
$1.1M
American Heart Association-American Stroke Association 23IPA1054908American Heart Association-American Stroke Association 23SCEFIA1157587American Heart Association-American Stroke Association 23TPA1141360NCI NIH HHS R01 CA287326NIBIB NIH HHS T32 EB027629
6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the rapidly growing neurodegenerative diseases, affecting more than 10 million people worldwide. Early and accurate diagnosis of PD is highly desirable for therapeutic interventions but remains a substantial challenge. We developed a soft, portable intelligent keyboard leveraging magnetoelasticity to detect subtle pressure variations in keystroke dynamics by converting continuous keystrokes into high-fidelity electrical signals, thus enabling the quantitative analysis of PD motor symptoms using machine learning. Relying on a fundamental working mechanism, the intelligent keyboard demonstrates highly sensitive, intrinsically waterproof, and biocompatible properties, with the successful demonstration in a pilot study on patients with PD. To facilitate the potential continuous monitoring of PD, a customized cellphone application was developed to integrate the intelligent keyboard into a wireless platform. Together, the intelligent keyboard system's compelling properties position it as a promising tool for advancing early diagnosis and facilitating personalized, predictive, preventative, and participatory approaches to PD healthcare.

Indexed as

BiometryParkinson DiseaseFemaleHumansMachine LearningMalePilot Projects

Identifiers

PMID40184462
PMCPMC11970477

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.