ArticleGigaScience2025
Phased high-quality genome of the gymnosperm Himalayan Yew assists in paclitaxel pathway exploration.
Article in GigaScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Archipelago architecture and evolution of paclitaxel biosynthesis revealed by the Pseudotaxus chienii haplotype-resolved genome.Nature communications · 2026Article
- Recent advances inFrontiers in plant science · 2026Review
- A high-quality chromosome-level reference genome of Pulsatilla chinensis.Scientific data · 2025Article
- Phased high-quality genome of the gymnosperm Himalayan Yew assists in paclitaxel pathway exploration.GigaScience · 2025Article
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Authors and funding
24 authors.
Funding
Abstract
backgroundTaxus wallichiana is an important species for paclitaxel production. Previous genome versions for Taxus spp. have been limited by extensive gaps, hindering the complete annotation and mining of paclitaxel (known as Taxol commercially) synthesis pathway-related genes.
resultsHere, we present the first phased high-quality reference genome of T. wallichiana, which significantly improves assembly quality and corrects large-scale assembly errors present in previous versions. The 2 haplotypes are 9.87 Gb and 9.98 Gb in length, respectively, and all 24 chromosomes were assembled with telomeres at both ends. Based on this high-quality genome (TWv1), we inferred that the candidate sex chromosome of T. wallichiana is chr12, and its sex determination system may follow a ZW model. Particularly, we identified and experimentally validated a batch of 2-oxoglutarate/Fe(II)-dependent dioxygenases (ODDs), which may be key C4β-C20 epoxidases in the paclitaxel synthesis pathway.
conclusionsThis study not only provides a valuable data resource for gene mining in the biosynthetic pathways of secondary metabolites, such as paclitaxel, but also offers the highest-quality reference genome of gymnosperms to date for the identification of sex chromosomes, facilitating comparative genomic studies among gymnosperms.
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