ReviewMolecular neurobiology2025
Orphan G Protein-Coupled Receptor GPR88: Mapping Its Significance in Central Nervous System Disorders.
Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Bioinformatics and experimental validation of druggable targets in non-alcoholic fatty liver disease.Scientific reports · 2026Article
- Constitutively active orphan G protein-coupled receptors through the lenses of cryo-electron microscopy.The Journal of biological chemistry · 2025Review
- Role and regulatory mechanism of GPR37 in neurological diseases.Frontiers in cellular neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
G protein-coupled receptors (GPCRs), comprising the largest family of membrane receptors in humans, play a crucial roles in various physiological and pathological processes. Although several drugs that target GPCRs have been discovered, the characterization of orphan GPCRs (oGPCRs) remains a significant challenge. Despite extensive research, knowledge on a significant portion of these receptors, along with their ligands and target sites, remains undefined. GPR88 belongs to the category of oGPCR that is expressed in various tissues and organs, with numerous studies indicating that it plays a regulatory role in cognitive processes, emotional responses, and motor control, thereby influencing various brain behaviors and functions associated with learning. Therefore, the purpose of this review was to thoroughly examine the role of GPR88 in various central nervous system diseases, with the ultimate aim of positioning it as a potential and promising target for drug development, particularly for the treatment of a broad spectrum of neurological disorders.
Indexed as
Identifiers
40184024What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.