Evidence map›Paper›PMID 40183981›Full record

ArticleIndian pediatrics2025

Utility of Fecal Biomarkers to Predict Invasive Nature of Acute Infectious Diarrhea in Indian Children.

Prabhav Aggarwal, Raghvendra Singh, Masoom Nathani, Sonal Saxena, Oves Siddiqui

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Article in Indian pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Prabhav AggarwalDepartment of Microbiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002, India. prabhavaggarwal@yahoo.co.in.
Raghvendra SinghDepartment of Pediatrics, Lok Nayak Hospital and Associated Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Masoom NathaniDepartment of Microbiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Sonal SaxenaDepartment of Microbiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Oves SiddiquiDepartment of Microbiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine role of fecal calprotectin (FC) and fecal lactoferrin (FL) in diagnosis of invasive diarrhea.

methodsStool samples from 75 children (≤ 12 years) with acute diarrhea were analysed using wet mount microscopy, culture, multiplex polymerase chain reaction, rapid tests for Rotavirus/ Adenovirus and quantitative ELISA for FC and FL.

resultsThe mean (SD) FC levels (μg/g) [774 (626.59) vs. 213 (251.48), P < 0.001] and FL levels (μg/g) [7.95 (4.72) vs. 4.22 (3.91), P = 0.004] were significantly higher in children with invasive diarrhea (n = 38) compared to those with non-invasive diarrhea (n = 37). Cut-off values of FC > 243 μg/g (sensitivity 81.57%, specificity 67.56%, AUC 0.813) and for FL > 6.02 μg/g (sensitivity 71.05%, specificity 81.08%, AUC 0.732) have diagnostic potential.

conclusionsFC and FL can aid diagnosis of acute invasive diarrhea.

Indexed as

DiarrheaFecesLactoferrinLeukocyte L1 Antigen ComplexAcute DiseaseBiomarkersChildChild, PreschoolFemaleHumansIndiaInfantMaleSensitivity and SpecificityBiomarkersLactoferrinLeukocyte L1 Antigen ComplexFecal calprotectinFecal lactoferrinInvasive pathogensPediatric population

Identifiers

PMID40183981

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