ArticleClinical oral investigations2025
Presumed periodontitis and multimorbidity patterns: a prospective cohort study in the UK Biobank.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations Between Multimorbidity, Polypharmacy and Oral Conditions in Older Adults: A Systematic Review and Meta-Analysis.Gerodontology · 2026Pooled it
- Exploring the associations between dietary nitrate and nitrite intake and markers of self-reported periodontal disease in the UK Biobank cohort.European journal of nutrition · 2026Article
- Oral Health, Inflammation, and the Burden of Multiple Long-Term Conditions: Cross-Sectional Analyses from UK Biobank and NHANES.Journal of clinical medicine · 2026Article
- Oral and cardiometabolic health through the lens of biobanks and large-scale epidemiologic research.Frontiers in oral health · 2026Review
- Periodontal Medicine: The Past, the Present, the Future.Journal of periodontal research · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo examine the pattern of multimorbidity among people with high risk of periodontitis. MATERIALS AND
methodsOver 358,000 UK Biobank participants aged 40-69 years at baseline who took part in the baseline assessment and answered mouth/teeth dental problems were included (2006-2010). Cox proportional hazard models and logistic regression models were used to estimate the association of the risk factors of periodontitis with chronic diseases and multimorbidity, stratified by follow-up time.
resultsA total of 154,985 participants developed multimorbidity during follow-up. We observed increased risk of multimorbidity among participants with presumed periodontitis (adjusted HR = 1.06, 95% confidence interval [CI] = 1.05-1.08), especially in those participants with age < 50 years old (adjusted HR = 1.11, 95% CI = 1.08-1.14). Among the different multimorbidity patterns, presumed periodontitis was mainly associated with the mental disorder pattern and metabolic and vascular disease pattern.
conclusionsPresumed periodontitis was positively associated with multimorbidity, even more so in younger age. We need to pay more attention to the prevention of periodontitis in the early stage to reduce the burden of multimorbidity in the future. CLINICAL RELEVANCE: Early life interventions to prevent periodontitis are crucial to reduce the incidence of multimorbidity and enhance the quality of life in older adults. Additionally, greater attention should be given to the mental and cardiovascular metabolic health of patients with periodontitis.
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