Evidence map›Paper›PMID 40183963›Full record

ArticleBioresources and bioprocessing2025

Unlocking the dual power of Charybdis natator shell: antiviral and larvicidal activities.

Karnan Ramachandran, Senthil Bakthavatchalam, Shunmuga Vadivu Ramalingam, Ramachandran Vinayagam, Mukeshwaran Ramesh, Sukumaran Marimuthu, Zhi-Hong Wen, Chandramohan Govindasamy, Khalid M Almutairi, Yi-Hao Lo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioresources and bioprocessing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karnan Ramachandran *PG and Research Department of Zoology, Rajah Serfoji Government College (Autonomous), Affiliated to Bharathidasan University, Thanjavur, Tamil Nadu, 613 005, India.
Senthil BakthavatchalamDepartment of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Ramapuram, Chennai, Tamil Nadu, 600089, India.
Shunmuga Vadivu RamalingamDepartment of Biochemistry, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, 600089, India.
Ramachandran Vinayagam *Department of Biotechnology, College of Life and Applied Sciences, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongsangbuk-do, 38541, Republic of Korea.
Mukeshwaran RameshACS Medical College, Chennai, India.
Sukumaran MarimuthuPG and Research Department of Zoology, Rajah Serfoji Government College (Autonomous), Affiliated to Bharathidasan University, Thanjavur, Tamil Nadu, 613 005, India.
Zhi-Hong WenNational Museum of Marine Biology and Aquarium, Pingtung, 94450, Taiwan.
Chandramohan GovindasamyDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, 11433, Riyadh, Saudi Arabia.
Khalid M AlmutairiDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, 11433, Riyadh, Saudi Arabia.
Yi-Hao LoDepartment of Family Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, 81342, Taiwan. loveangelsome@gmail.com.

Funding

Ministry of Science and Technology, Taiwan NSTC-113-2314-B-283-001Zuoying Armed forces GENERAL Hospital KAFGH-ZY-A-114013
6 · The paper itself

Abstract

This study investigates the in silico anti-arboviral potential of zoochemicals derived from the methanolic extract of Charybdis natator shell, alongside their larvicidal efficacy against Aedes aegypti 4th instar larvae. Through GC-MS analysis, 27 zoochemicals were identified, demonstrating promising in silico activity against molecular antiviral targets: DENV2 protease (PDB: 6MO1) for anti-dengue, RNA polymerase (PDB: 5U04) for anti-Zika, and nsP2 protease (PDB: 3TRK) for anti-chikungunya. A strong positive correlation (r = 0.726-0.889) in binding affinities (kcal/mol) suggests a consistent inhibitory mechanism across these targets. Furthermore, PASS analysis indicates higher probabilities of activity (Pa) for insecticidal properties compared to antiviral efficacy, highlighting their dual potential as larvicidal agents and antiviral candidates. The methanolic extract of Charybdis natator shell exhibited potent larvicidal activity against Aedes aegypti (LC₅₀ = 81.001 µg/mL) in a dose-dependent manner (R

Indexed as

AntiviralArbovirus vectorCharybdis natatorCrab zoochemicalsZoo-virucide

Identifiers

PMID40183963
PMCPMC11971121

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.