ArticleEuropean journal of nuclear medicine and molecular imaging2025
Pleasurable music activates cerebral µ-opioid receptors: a combined PET-fMRI study.
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of different art therapies on the psychological well-being and quality of life in cancer survivors: a systematic review and network meta-analysis.Frontiers in psychiatry · 2026Pooled it
- A dual-database bibliometric analysis of music-based interventions and pain from 2004 to 2024.Frontiers in medicine · 2025Pooled it
- Expressing emotions through music.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Music engages the phasic dopaminergic D1-receptor system in humans: a PET-fMRI study using [European journal of nuclear medicine and molecular imaging · 2026Article
- Potential Effects of Music on Non-Motor Symptoms in Parkinson's Disease: Translating Mechanisms to Therapy.Neurology international · 2026Review
- Social engagement, pleasure, and memory in musical reminiscence workshops for individuals with Alzheimer's disease.Frontiers in human neuroscience · 2026Article
- Initial Exploration of a Music-Based Telehealth Support for Medically-Complex Chronic Pain Patients.Journal of pain research · 2026Article
- Why friendship and loneliness affect our health.Annals of the New York Academy of Sciences · 2025Review
- The therapeutic use of music for chronic pain: a psychological and neurobiological perspective.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeThe μ-opioid receptor (MOR) system mediates incentive motivation and the hedonic component of primary rewards such as food and sex. However, there is no direct in vivo evidence for the involvement of the MOR system in pleasure derived from aesthetic rewards such as music.
methodsWe measured MOR availability with positron emission tomography (PET) and the agonist radioligand [
resultsThe PET results revealed that pleasurable music increased [
conclusionsThese findings provide the first neuroimaging evidence that pleasurable music modulates MOR system function. The results indicate that the μ-opioid system governs complex aesthetic rewards in addition to biologically essential primary rewards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.