Evidence map›Paper›PMID 40183935›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Adamantinomatous craniopharyngioma stone: is it a tumor?

Sérgio Cavalheiro, Lorena Favaro Pavon, Marcos Devanir Silva da Costa, Patrícia Alesssandra Dastoli, Rodrigo Akira Watanabe, Isaque Hyung Tong Kim, Fernando Seiji Suzuki, Flávia Borelli Nascimento, Khallil Taverna Chaim, Francisco Romero Cabral and 2 more

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Sérgio CavalheiroDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Lorena Favaro PavonDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil. lorena.fpporfirio@gmail.com.
Marcos Devanir Silva da CostaDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Patrícia Alesssandra DastoliDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Rodrigo Akira WatanabeDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Isaque Hyung Tong KimDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Fernando Seiji SuzukiDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Flávia Borelli NascimentoDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Khallil Taverna ChaimDepartment of Radiology, Faculty of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Francisco Romero CabralFaculty of Medical Sciences, Santa Casa de São Paulo, São Paulo, Brazil.
Silvia Regina Caminada ToledoNational Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology - INCT BioOncoPed, Porto Alegre, Brazil.
Tatiana Tais SibovDepartment of Neurology and Neurosurgery, Translational Neurosurgery Laboratory Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdamantinomatous craniopharyngioma (ACP) is a benign epithelial tumor of the sellar and suprasellar region, and in children, it usually presents with cysts and calcifications.

methodsIn this study, ACP samples were collected, and after enzymatic digestion of the calcified component of these tumors, which were placed in culture to isolate possible cellular components, in vitro and in vivo viability analysis and characterization were performed.

resultsACP-calcified component cells cultured in vitro were established showing the doubling time in 2 days, confirmed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Other analyses were carried out, such as ultrastructural characterization and the growth of ACP-calcified component cells in xenograft animal model by MRI monitoring. Immunocytochemistry detected cytokeratin-7 expression in the cytomembrane and cytoplasm of ACP-calcified component cells, confirming that the tumor mass established in the xenograft animal model comes from calcified component of ACP patients' cell cultures which were squamous epithelial cells.

conclusionsThus, our results suggest that the calcifications present in ACPs have the capacity to generate a tumor, and we could only consider complete tumor excision when all calcifications have been removed. Therefore, these ACP-calcified component cell cultures may be important to study possible targets for drug therapies and help understand the progression mechanisms of this tumor and better control its spread.

Indexed as

CalcinosisCraniopharyngiomaPituitary NeoplasmsAnimalsChildFemaleHumansMagnetic Resonance ImagingMaleMiceCraniopharyngiomaMRIPrimary cultureXenograft model

Identifiers

PMID40183935

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