ArticleJournal of veterinary science2025
Molecular epidemiology and genetic characteristics of pseudorabies virus between 2021 and 2023 in Henan Province of China.
Article in Journal of veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Characterization of a monoclonal antibody recognizing a conserved linear neutralizing epitope of pseudorabies virus gB protein.Archives of microbiology · 2026Article
- Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)-Induced Reactive Oxygen Species Inhibit Phagocytosis in Alveolar Macrophages.International journal of molecular sciences · 2026Article
- Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1-STAT1 interaction.Virologica Sinica · 2026Article
- Persistent Circulation of Pseudorabies Virus Variants in China: Genomic Features, Pathogenic Characteristics, and Cross-Protective Efficacy of Variant Strain Vaccines.Transboundary and emerging diseases · 2026Article
- Antiviral Activity of Diltiazem HCl Against Pseudorabies Virus Infection In Vitro.Veterinary sciences · 2025Article
- Antiviral activity of nitazoxanide against pseudorabies virus infectionFrontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
importancePseudorabies (PR) is a significant disease that adversely affects the healthy growth of the pig industry in China. However, data on molecular epidemiology and genetic characterization of PRV is sparse.
objectiveThis study examined the epidemic trends and variation characteristics of the PR virus (PRV) in Henan Province of China.
methodsSix hundred eighty-eight clinically infected pig tissue samples were collected from 18 cities in Henan Province from January 2021 to March 2023 and tested for the PRV. The PRV was isolated from positive samples and identified by a polymerase chain reaction and immunofluorescence assay. The
resultsThe positive rate of PRV nucleic acid was 7.99% (55/688) in Henan Province, China. This study isolated eight PRV strains, all of which were genotype II variants. Seven isolates displayed unique amino acid mutations in the gC or gE proteins. The isolates of G22, HN4, QX, and QX2 can cause acute neurological symptoms in KM mice, with 50% lethal dose values of 10 CONCLUSIONS AND RELEVANCE: This study revealed a high prevalence of the PRV in Henan Province, with genotype II variants being the predominant strains. These findings provide essential data for the prevention and control of the PRV.
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