Evidence map›Paper›PMID 40183909›Full record

ArticleJournal of veterinary science2025

A novel thrombospondin-1 variant as a potential diagnostic biomarker and therapeutic target in canine mammary tumor and osteosarcoma cells.

Yukyung Hong, Heyeon Baik, Jeongmin Lee, Won Seok Oh, Junsun Ryu, Seung Joon Baek

Abstract read
In one paragraph

Article in Journal of veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. TheCancers · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yukyung Hong *College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-3018-4539
Heyeon Baik *College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-8897-4365
Jeongmin LeeKorea Animal Medical Center, Cheongju 28651, Korea.ORCID https://orcid.org/0000-0003-2920-7171
Won Seok OhCenter for Veterinary Integrative Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-9247-7927
Junsun RyuDepartment of Otolaryngology-Head and Neck Surgery, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang 10408, Korea. jsryu@ncc.re.kr.ORCID https://orcid.org/0000-0002-6730-6755
Seung Joon BaekCollege of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea. baeksj@snu.ac.kr.ORCID https://orcid.org/0000-0001-7866-7778

Funding

Creative Veterinary Science Research Center, Seoul National UniversityNational Cancer Center NCC2510420-1National Research Foundation of Korea 2018R1A2B200292314
6 · The paper itself

Abstract

importanceThrombospondin-1 (TSP1) is a vital glycoprotein that plays a key role in critical biological functions, including cell migration, invasion, angiogenesis, and proliferation. Understanding the roles of its variants, particularly TSP1 variant (TSP1V), is critical for cancer biology and therapy.

objectiveThis study examined the expression of the transcriptional variant TSP1V, focusing on canine TSP1 sequences.

methodsThe expression of canine TSP1 sequences was analyzed using a reverse transcription polymerase chain reaction (RT-PCR) to identify the

resultsTwo CONCLUSIONS AND RELEVANCE: TSP1V may be a potential diagnostic biomarker and therapeutic target for mammary tumors and osteosarcoma in dogs. The differential expression of

Indexed as

Biomarkers, TumorBone NeoplasmsDog DiseasesMammary Neoplasms, AnimalOsteosarcomaThrombospondin 1AnimalsCell Line, TumorCell ProliferationDogsFemaleGenisteinBiomarkers, TumorGenisteinThrombospondin 1Biomarkercanine mammary tumordamnacanthalosteosarcomathrombospondin-1

Identifiers

PMID40183909
PMCPMC11972944

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.