Evidence map›Paper›PMID 40183869›Full record

ArticleClinical and experimental nephrology2025

Prognosis of patients diagnosed with latent tuberculosis infection at dialysis initiation.

Mea Aso, Kaori Kohatsu, Suguru Takayama, Takuya Matsuda, Shigeki Kojima, Yugo Shibagaki, Tsutomu Sakurada

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Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Mea AsoDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan.
Kaori KohatsuDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan.
Suguru TakayamaDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan.
Takuya MatsudaDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan.
Shigeki KojimaDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan.
Yugo ShibagakiDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan.
Tsutomu SakuradaDivision of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan. sakurada@marianna-u.ac.jp.ORCID http://orcid.org/0000-0003-2434-0483

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognosis of Japanese dialysis patients diagnosed with latent tuberculosis infection (LTBI) at the time of starting dialysis remains unclear. The purpose of this study was to examine whether there is a difference in prognosis between incident dialysis patients with and without LTBI.

methodsA retrospective study of incident dialysis patients who underwent an interferon-gamma release assay (T-SPOT test) within 1 year before or after dialysis initiation at our hospital between May 1, 2013, and December 31, 2021 was conducted. Using propensity score matching (PSM), survival of the non-LTBI and LTBI groups was compared after adjusting for patient background characteristics.

resultsOf the 737 incident dialysis patients, 276 (37.4%) underwent the T-SPOT test, of whom 23 (8.3%) were diagnosed with LTBI. After matching for age, sex, activities of daily living (ADL), estimated glomerular filtration rate (eGFR), Charlson comorbidity index (CCI), and serum albumin level, 23 patients were selected for each group. Kaplan-Meier analysis showed a significantly lower cumulative survival rate in the LTBI group (p = 0.048, log-rank test). In the LTBI group, the cumulative survival rate tended to be higher in the LTBI-treated group (n = 13) than in the untreated group (n = 10) (p = 0.089).

conclusionPatients with LTBI at dialysis initiation have a poorer prognosis than those without LTBI, and LTBI treatment may improve their prognosis. This study emphasizes the clinical importance and necessity of managing LTBI in dialysis patients.

Indexed as

Latent TuberculosisRenal DialysisAdultAgedFemaleHumansInterferon-gamma Release TestsJapanMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsTime FactorsDialysis initiationLatent tuberculosis infection (LTBI)MortalityPrognosis

Identifiers

PMID40183869

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